The RSK family of kinases: emerging roles in cellular signalling.

The RSK family of kinases: emerging roles in cellular signalling.

The 90 kDa ribosomal S6 kinase (RSK) household of proteins is a gaggle of extremely conserved Ser/Thr kinases that regulate various mobile processes, resembling cell progress, cell motility, cell survival and cell proliferation. RSKs are downstream effectors of the Ras-extramobile signal-regulated kinase (ERK)/mitogen-activated … Read More

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways.

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways.

Bioactive compounds might be helpful analysis instruments and drug leads, however it’s usually tough to establish their mechanism of motion or mobile goal. Right here we examine the potential for integration of chemical-genetic and genetic interplay information to disclose details about the pathways and targets of … Read More

Fluorescence probes used for detection of reactive oxygen species.

Fluorescence probes used for detection of reactive oxygen species.

Endogenously produced pro-oxidant reactive species are important to life, being concerned in a number of organic features. Nevertheless, when overproduced (e.g. attributable to exogenous stimulation), or when the degrees of antioxidants grow to be severely depleted, these reactive species grow … Read More

The consensus coding sequences of human breast and colorectal cancers.

The consensus coding sequences of human breast and colorectal cancers.

The elucidation of the human genome sequence has made it potential to ascertain genetic alterations in cancers in unprecedented component. To start out a scientific analysis of such alterations, we determined the sequence of well-annotated human protein-coding genes in two … Read More

Reaching for the cloud: on the lessons learned from grid computing technology transfer process to the biomedical community.

Reaching for the cloud: on the lessons learned from grid computing technology transfer process to the biomedical community.

Pure scientists corresponding to physicists pioneered the sharing of computing sources, which led to the creation of the Grid. The inter area switch technique of this know-how has hitherto been an intuitive course of with out in depth evaluation. Some … Read More

The BioIntelligence Framework: a new computational platform for biomedical knowledge computing.

The BioIntelligence Framework: a new computational platform for biomedical knowledge computing.

Breakthroughs in molecular profiling applied sciences are enabling a brand new data-intensive strategy to biomedical analysis, with the potential to revolutionize how we examine, handle, and deal with advanced ailments. The following nice problem for scientific functions of those improvements … Read More

Structural biology computing: Lessons for the biomedical research sciences.

Structural biology computing: Lessons for the biomedical research sciences.

The sector of structural biology, whose goal is to elucidate the molecular and atomic constructions of organic macromolecules, has lengthy been on the forefront of biomedical sciences in adopting and creating computational analysis strategies. Working on the intersection between biophysics, … Read More

HPC AND GRID COMPUTING FOR INTEGRATIVE BIOMEDICAL RESEARCH.

HPC AND GRID COMPUTING FOR INTEGRATIVE BIOMEDICAL RESEARCH.

Integrative biomedical analysis initiatives question, analyze, and combine many various knowledge varieties and make use of datasets obtained from measurements or simulations of construction and performance at a number of organic scales. With the rising availability of high-throughput and high-resolution … Read More

Extending the dynamic range of biomedical micro-computed tomography for application to geomaterials.

Extending the dynamic range of biomedical micro-computed tomography for application to geomaterials.

X-ray computed tomography (CT) can non-destructively look at objects by producing three-dimensional photographs of their inner construction. Though the provision of biomedical micro-CT affords the elevated entry to scanners, CT photographs of dense objects are vulnerable to artifacts notably as … Read More

Quantitative X-ray phase contrast computed tomography with grating interferometry : Biomedical applications of quantitative X-ray grating-based phase contrast computed tomography

Quantitative X-ray phase contrast computed tomography with grating interferometry : Biomedical applications of quantitative X-ray grating-based phase contrast computed tomography

The flexibility of biomedical imaging knowledge to be of quantitative nature is getting more and more necessary with the continued developments in knowledge science. In distinction to standard attenuation-based X-ray imaging, grating-based section distinction computed tomography (GBPC-CT) is a section … Read More