An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.

Small molecule inhibitors of protein kinases are extensively utilized in sign transduction analysis and are rising as a significant class of medication. Though interpretation of organic outcomes obtained with these reagents critically is determined by their selectivity, environment friendly strategies for proteome-wide evaluation of kinase inhibitor selectivity haven’t but been reported.
Right here, we handle this vital problem and describe a way for figuring out targets of the extensively used p38 kinase inhibitor SB 203580. Immobilization of an acceptable SB 203580 analogue and totally optimized biochemical situations for affinity chromatography permitted the dramatic enrichment and identification of a number of beforehand unknown protein kinase targets of SB 203580.
In vitro kinase assays confirmed that cyclin G-associated kinase (GAK) and CK1 have been nearly as potently inhibited as p38alpha whereas RICK [Rip-like interacting caspase-like apoptosis-regulatory protein (CLARP) kinase/Rip2/CARDIAK] was much more delicate to inhibition by SB 203580. The mobile kinase exercise of RICK, a recognized sign transducer of inflammatory responses, was already inhibited by submicromolar concentrations of SB 203580 in intact cells.
Due to this fact, our outcomes warrant a reevaluation of the huge quantity of knowledge obtained with SB 203580 and may need important implications on the event of p38 inhibitors as antiinflammatory medicine. Primarily based on the procedures described right here, environment friendly affinity purification methods might be developed for different protein kinase inhibitors, offering essential details about their mobile modes of motion.
The immunological processes concerned within the collaborative defence of organisms are affected by dietary standing. Thus, a optimistic continual imbalance between power consumption and expenditure results in conditions of weight problems, which can affect unspecific and particular immune responses mediated by humoral and cell mediated mechanisms.
Moreover, a number of traces of proof have supported a hyperlink between adipose tissue and immunocompetent cells. This interplay is illustrated in weight problems, the place extra adiposity and impaired immune perform have been described in each people and genetically overweight rodents.
Nevertheless, restricted and sometimes controversial info exist evaluating immunity in overweight and non-obese topics in addition to concerning the mobile and molecular mechanisms implicated. Normally phrases, scientific and epidemiological knowledge assist the proof that the incidence and severity of particular forms of infectious diseases are increased in overweight individuals as in comparison with lean people along with the incidence of poor antibody responses to antigens in obese topics.
Leptin would possibly play a key function in linking dietary standing with T-cell perform. The complexities and heterogeneity of the host defences in regards to the immune response in several dietary circumstances affecting the power steadiness require an integral examine of the immunocompetent cells, their subsets and merchandise in addition to particular and unspecific inducer/regulator techniques. On this context, extra analysis is required to make clear the scientific implications of the alterations induced by weight problems on the immune perform.

Runx1 is required for zebrafish blood and vessel growth and expression of a human RUNX1-CBF2T1 transgene advances a mannequin for research of leukemogenesis.

RUNX1/AML1/CBFA2 is important for definitive hematopoiesis, and chromosomal translocations affecting RUNX1 are incessantly concerned in human leukemias. Consequently, the traditional perform of RUNX1 and its involvement in leukemogenesis stay topic to intensive analysis.
To additional elucidate the function of RUNX1 in hematopoiesis, we cloned the zebrafish ortholog (runx1) and analyzed its perform utilizing this mannequin system. Zebrafish runx1 is expressed in hematopoietic and neuronal cells throughout early embryogenesis. runx1 expression within the lateral plate mesoderm co-localizes with the hematopoietic transcription issue scl, and expression of runx1 is markedly diminished within the zebrafish mutants spadetail and cloche.
Transient expression of runx1 in cloche embryos resulted in partial rescue of the hematopoietic defect. Depletion of Runx1 with antisense morpholino oligonucleotides abrogated the event of each blood and vessels, as demonstrated by lack of circulation, incomplete growth of vasculature and the buildup of immature hematopoietic precursors.
The block in definitive hematopoiesis is just like that noticed in Runx1 knockout mice, implying that zebrafish Runx1 has a perform equal to that in mammals. Our knowledge counsel that zebrafish Runx1 capabilities in each blood and vessel growth on the hemangioblast degree, and contributes to each primitive and definitive hematopoiesis. Depletion of Runx1 additionally induced aberrant axonogenesis and irregular distribution of Rohon-Beard cells, offering the primary practical proof of a task for vertebrate Runx1 in neuropoiesis.
To offer a base for analyzing the function of Runx1 in leukemogenesis, we investigated the results of transient expression of a human RUNX1-CBF2T1 transgene [product of the t(8;21) translocation in acute myeloid leukemia] in zebrafish embryos.
Expression of RUNX1-CBF2T1 induced disruption of regular hematopoiesis, aberrant circulation, inside hemorrhages and mobile dysplasia. These defects reproduce these noticed in Runx1-depleted zebrafish embryos and RUNX1-CBF2T1 knock-in mice. The phenotype obtained with transient expression of RUNX1-CBF2T1 validates the zebrafish as a mannequin system to check t(8;21)-mediated leukemogenesis.

From in vivo to in silico biology and again.

The large acquisition of knowledge in molecular and mobile biology has led to the renaissance of an outdated matter: simulations of organic techniques. Simulations, more and more paired with experiments, are being efficiently and routinely utilized by computational biologists to know and predict the quantitative behaviour of complicated techniques, and to drive new experiments.
However, many experimentalists nonetheless think about simulations an esoteric self-discipline just for initiates. Suspicion in the direction of simulations ought to dissipate as the restrictions and benefits of their utility are higher appreciated, opening the door to their everlasting adoption in on a regular basis analysis.

Proteome-wide evaluation of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.

Submit-translational modification of proteins by lysine acetylation performs vital regulatory roles in residing cells. The budding yeast Saccharomyces cerevisiae is a extensively used unimobile eukaryotic mannequin organism in biomedical analysis.
S. cerevisiae accommodates a number of evolutionary conserved lysine acetyltransferases and deacetylases. Nevertheless, just a few dozen acetylation websites in S. cerevisiae are recognized, presenting a significant impediment for additional understanding the regulatory roles of acetylation on this organism.
An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.
Right here we use excessive decision mass spectrometry to determine about 4000 lysine acetylation websites in S. cerevisiae. Acetylated proteins are implicated within the regulation of numerous cytoplasmic and nuclear processes together with chromatin group, mitochondrial metabolism, and protein synthesis.
Bioinformatic evaluation of yeast acetylation websites reveals that acetylated lysines are considerably extra conserved in contrast with nonacetylated lysines. A big fraction of the conserved acetylation websites are current on proteins concerned in mobile metabolism, protein synthesis, and protein folding. Moreover, quantification of the Rpd3-regulated acetylation websites recognized a number of beforehand recognized, in addition to new putative substrates of this deacetylase.

Superoxide Dismutase Antibody

abx022850-1ml 1 ml
EUR 1053.6

Human Superoxide Dismutase

90240-A 20 µg
EUR 130
Description: SOD is a disulfide-linked homodimeric protein consisting of two 154 amino acid residues, and migrates as an approximately 31 kDa protein under non-reducing and as 16 kDa under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Superoxide Dismutase mature chain was expressed in E. coli.

Human Superoxide Dismutase

90240-B 100 µg
EUR 205
Description: SOD is a disulfide-linked homodimeric protein consisting of two 154 amino acid residues, and migrates as an approximately 31 kDa protein under non-reducing and as 16 kDa under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Superoxide Dismutase mature chain was expressed in E. coli.

Superoxide Dismutase 3 Antibody (SOD3)

F52953-0.08ML 0.08 ml
EUR 140.25
Description: SOD3 protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.

Superoxide Dismutase 3 Antibody (SOD3)

F49928-0.08ML 0.08 ml
EUR 140.25
Description: SOD3 is a member of the superoxide dismutase(SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. This protein is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.

Superoxide Dismutase 3 Antibody / SOD3

RQ4091 100 ug
EUR 356.15
Description: SOD3 (Superoxide Dismutase 3), also called Superoxide Dismutase extracellular, EC-SOD, and Cu-Zn, is an enzyme that in humans is encoded by the SOD3 gene. This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. Hendrickson et al. (1990) mapped the SOD3 gene to 4pter-q21 by a study of somatic cell hybrids. Stern et al. (2003) narrowed the assignment to 4p15.3-p15.1 by somatic cell and radiation hybrid analysis, linkage mapping, and FISH. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.

SOD3 Antibody / Superoxide Dismutase 3

R30999 100 ug
EUR 356.15
Description: Superoxide Dismutase 3 is an enzyme that in humans is encoded by the SOD3 gene. This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. Hendrickson et al.(1990) mapped the SOD3 gene to 4pter-q21 by a study of somatic cell hybrids. Stern et al.(2003) narrowed the assignment to 4p15.3-p15.1 by somatic cell and radiation hybrid analysis, linkage mapping, and FISH. The product of this gene is though to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix(ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.

Superoxide Dismutase 3 Antibody / SOD3

R31796 100 ug
EUR 356.15
Description: SOD3 (SUPEROXIDE DISMUTASE 3), also called SUPEROXIDE DISMUTASE, EXTRACELLULAR, EC-SOD, and Cu-Zn, is an enzyme that in humans is encoded by the SOD3 gene. This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. Hendrickson et al. (1990) mapped the SOD3 gene to 4pter-q21 by a study of somatic cell hybrids. Stern et al. (2003) narrowed the assignment to 4p15.3-p15.1 by somatic cell and radiation hybrid analysis, linkage mapping, and FISH. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.

Superoxide dismutase 3 Antibody / Sod3

RQ6518 100ug
EUR 356.15
Description: SOD3 (SUPEROXIDE DISMUTASE 3), also called SUPEROXIDE DISMUTASE, EXTRACELLULAR, EC-SOD, and Cu-Zn, is an enzyme that in humans is encoded by the SOD3 gene. This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. Hendrickson et al. (1990) mapped the SOD3 gene to 4pter-q21 by a study of somatic cell hybrids. Stern et al. (2003) narrowed the assignment to 4p15.3-p15.1 by somatic cell and radiation hybrid analysis, linkage mapping, and FISH. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.

Superoxide Dismutase protein

30R-2714 100 ug
EUR 542.4
Description: Purified recombinant Human Superoxide Dismutase protein

Superoxide Dismutase 2 antibody

10R-7478 100 ul
EUR 471.6
Description: Mouse monoclonal Superoxide Dismutase 2 antibody

Superoxide Dismutase 2 antibody

10R-7479 100 ul
EUR 471.6
Description: Mouse monoclonal Superoxide Dismutase 2 antibody

Superoxide Dismutase 1 antibody

10R-7482 100 ul
EUR 471.6
Description: Mouse monoclonal Superoxide Dismutase 1 antibody

Superoxide Dismutase 1 antibody

10R-7483 100 ul
EUR 471.6
Description: Mouse monoclonal Superoxide Dismutase 1 antibody

Superoxide Dismutase 4 antibody

10R-7484 100 ul
EUR 471.6
Description: Mouse monoclonal Superoxide Dismutase 4 antibody

Superoxide Dismutase 4 antibody

10R-7485 100 ul
EUR 471.6
Description: Mouse monoclonal Superoxide Dismutase 4 antibody

Superoxide Dismutase 1 Antibody

49350-100ul 100ul
EUR 399.6

Superoxide Dismutase 1 Antibody

49350-50ul 50ul
EUR 286.8

Superoxide Dismutase 1, Human

LF-P0010 0.5 mg
EUR 242.4
Description: Superoxide Dismutase 1, Human protein

Superoxide Dismutase 2, Human

LF-P0013 0.5 mg
EUR 242.4
Description: Superoxide Dismutase 2, Human protein

Superoxide Dismutase 4, Human

LF-P0020 0.5 mg
EUR 242.4
Description: Superoxide Dismutase 4, Human protein

Superoxide Dismutase 4, mouse

LF-P0410 0.5 mg
EUR 363.6
Description: Superoxide Dismutase 4, mouse protein

Superoxide Dismutase (SOD1) Antibody

abx414380-01mg 0.1 mg
EUR 526.8

Superoxide Dismutase Assay Kit

abx096009-100Assays 100 Assays
EUR 566.4

SOD, Superoxide Dismutase, human

RC512-12 20ug
EUR 125.26

Chicken Superoxide Dismutase (SOD)

QY-E80142 96T
EUR 511.2

Superoxide Dismutase 3 (SOD-3) Antibody (1H12)

6170-100 each
EUR 483.6

Superoxide Dismutase Standard, 1EA

C098-1EA 1EA
EUR 109

Native Plant Superoxide Dismutase

NATE-1619 1g
EUR 324

Rabbit Anti-human Superoxide Dismutase 3 (SOD3) IgG

SOD32-A 100 ug
EUR 578.4

Superoxide Dismutase (SOD-1) Antibody

3458-100 each
EUR 392.4

Superoxide Dismutase (SOD-1) Antibody

3458-30T each
EUR 175.2

Superoxide Dismutase 2 Antibody (SOD2)

F50529-0.08ML 0.08 ml
EUR 140.25
Description: SOD2 is a member of the iron/manganese superoxide dismutase family. It is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer.

Superoxide Dismutase 1 Antibody (SOD1)

F51318-0.08ML 0.08 ml
EUR 140.25
Description: SOD1 binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. This isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein.

Superoxide Dismutase 2 Antibody / SOD2

F54062-0.1ML 0.1 ml
EUR 322.15
Description: Superoxide dismutase 2 is a member of the iron/manganese superoxide dismutase family. The SOD2 gene encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. [Wiki]

Superoxide Dismutase 2 Antibody / SOD2

F54485-0.05ML 0.05 ml
EUR 140.25
Description: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Superoxide Dismutase 2 Antibody / SOD2

F54485-0.2ML 0.2 ml
EUR 330.65
Description: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Superoxide Dismutase 2 Antibody (SOD2)

F40411-0.08ML 0.08 ml
EUR 140.25
Description: This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

SOD1 Antibody Superoxide Dismutase 1

R30411 100 ug
EUR 356.15
Description: Superoxide dismutases are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. As such, they are an important antioxidant defense in nearly all cells exposed to oxygen. One of the exceedingly rare exceptions is Lactobacillus plantarum and related lactobacilli, which use a different mechanism.Cu,Zn-SOD was found widely distributed in the cell cytosol and in the cell nucleus, consistent with it being a soluble cytosolic protein. Mitochondria and secretory compartments did not label for this protein. In human cells, peroxisomes showed a labeling density slightly less than that of cytoplasm.

SOD2 Antibody Superoxide Dismutase 2

R30869 100 ug
EUR 356.15
Description: Superoxide Dismutase 2, also called IPO-B or MNSOD, is a mitochondrial matrix enzyme that scavenges oxygen radicals produced by the extensive oxidation-reduction and electron transport reactions occurring in mitochondria. This gene is a member of the iron/manganese superoxide dismutase family. Using a somatic cell hybrid panel containing different segments of chromosome 6, they demonstrated that SOD2 is located in the region 6q25.3-qter which, together with the FISH analysis, indicated that the enzyme is in the distal portion of 6q25. The gene encodes an intramitochondrial free radical scavenging enzyme that is the first line of defense against superoxide produced as a byproduct of oxidative phosphorylation. Adeno-associated viral delivery of the human gene resulted in suppression of optic nerve degeneration and rescue of retinal ganglion cells. The findings suggested that reactive oxygen species contributed to retinal cell death and optic nerve damage in mice with complex I deficiency, and that expression of SOD2 attenuated the disease process.

Superoxide Dismutase 1 Antibody (SOD1)

R31855 100 ug
EUR 356.15
Description: Superoxide dismutases (SOD) are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. As such, they are an important antioxidant defense in nearly all cells exposed to oxygen. One of the exceedingly rare exceptions is Lactobacillus plantarum and related lactobacilli, which use a different mechanism.Cu,Zn-SOD was found widely distributed in the cell cytosol and in the cell nucleus, consistent with it being a soluble cytosolic protein. Mitochondria and secretory compartments did not label for this protein. In human cells, peroxisomes showed a labeling density slightly less than that of cytoplasm.

Superoxide Dismutase 2 Antibody / SOD2

R31882 100 ug
EUR 356.15
Description: SOD2 (Superoxide Dismutase 2), also called IPO-B or MNSOD, is a mitochondrial matrix enzyme that scavenges oxygen radicals produced by the extensive oxidation-reduction and electron transport reactions occurring in mitochondria. This gene is a member of the iron/manganese superoxide dismutase family. Using a somatic cell hybrid panel containing different segments of chromosome 6, they demonstrated that SOD2 is located in the region 6q25.3-qter which, together with the FISH analysis, indicated that SOD2 is in the distal portion of 6q25. The SOD2 gene encodes an intramitochondrial free radical scavenging enzyme that is the first line of defense against superoxide produced as a byproduct of oxidative phosphorylation. Adeno-associated viral delivery of the human SOD2 gene resulted in suppression of optic nerve degeneration and rescue of retinal ganglion cells. The findings suggested that reactive oxygen species contributed to retinal cell death and optic nerve damage in mice with complex I deficiency, and that expression of SOD2 attenuated the disease process.

Superoxide Dismutase 2 Antibody / SOD2

RQ7037 100 ug
EUR 356.15
Description: SOD2 (Superoxide Dismutase 2), also called IPO-B or MNSOD, is a mitochondrial matrix enzyme that scavenges oxygen radicals produced by the extensive oxidation-reduction and electron transport reactions occurring in mitochondria. This gene is a member of the iron/manganese superoxide dismutase family. Using a somatic cell hybrid panel containing different segments of chromosome 6, they demonstrated that SOD2 is located in the region 6q25.3-qter which, together with the FISH analysis, indicated that SOD2 is in the distal portion of 6q25. The SOD2 gene encodes an intramitochondrial free radical scavenging enzyme that is the first line of defense against superoxide produced as a byproduct of oxidative phosphorylation. Adeno-associated viral delivery of the human SOD2 gene resulted in suppression of optic nerve degeneration and rescue of retinal ganglion cells. The findings suggested that reactive oxygen species contributed to retinal cell death and optic nerve damage in mice with complex I deficiency, and that expression of SOD2 attenuated the disease process.

Superoxide Dismutase 2 Antibody / SOD2

RQ5041 100ul
EUR 356.15
Description: 'Superoxide dismutase [Mn], mitochondrial' destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. [UniProt]

SOD1 Antibody / Superoxide Dismutase 1

V8968-100UG 100ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8968-20UG 20ug
EUR 153.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8968SAF-100UG 100ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V9162-100UG 100ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V9162-20UG 20ug
EUR 153.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V9162SAF-100UG 100ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V3869-100UG 100 ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V3869-20UG 20 ug
EUR 153.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V3869SAF-100UG 100 ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8619-100UG 100 ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8619-20UG 20 ug
EUR 153.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8619SAF-100UG 100 ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8620-100UG 100 ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8620-20UG 20 ug
EUR 153.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8620SAF-100UG 100 ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8621-100UG 100 ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8621-20UG 20 ug
EUR 153.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8621SAF-100UG 100 ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8622-100UG 100 ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8622-20UG 20 ug
EUR 153.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8622SAF-100UG 100 ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8623-100UG 100 ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8623-20UG 20 ug
EUR 153.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8623SAF-100UG 100 ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8624-100UG 100 ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8624-20UG 20 ug
EUR 153.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

SOD1 Antibody / Superoxide Dismutase 1

V8624SAF-100UG 100 ug
EUR 349.3
Description: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

Native Bovine Superoxide Dismutase

NATE-0675 125mg
EUR 324

Dog Superoxide Dismutase ELISA kit

E08S0012-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Superoxide Dismutase ELISA kit

E08S0012-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Superoxide Dismutase ELISA kit

E08S0012-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Superoxide Dismutase ELISA kit

E02S0012-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Superoxide Dismutase ELISA kit

E02S0012-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Superoxide Dismutase ELISA kit

E02S0012-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Superoxide Dismutase ELISA kit

E07S0012-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Superoxide Dismutase ELISA kit

E07S0012-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Superoxide Dismutase ELISA kit

E07S0012-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Superoxide Dismutase ELISA kit

E06S0012-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Superoxide Dismutase ELISA kit

E06S0012-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Superoxide Dismutase ELISA kit

E06S0012-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Recombinant E.Coli Superoxide Dismutase

7-06481 5µg Ask for price

Recombinant E.Coli Superoxide Dismutase

7-06482 20µg Ask for price

Recombinant E.Coli Superoxide Dismutase

7-06483 1mg Ask for price

Superoxide Dismutase [Mn] (SODA) Protein

20-abx261368
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Mouse Superoxide Dismutase ELISA kit

E03S0012-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Superoxide Dismutase ELISA kit

E03S0012-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Superoxide Dismutase ELISA kit

E03S0012-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Superoxide Dismutase ELISA kit

E01S0012-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Superoxide Dismutase ELISA kit

E01S0012-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Superoxide Dismutase ELISA kit

E01S0012-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Superoxide Dismutase 1 (SOD-1) Antibody

6641-100 each
EUR 379.2

Superoxide Dismutase 1 (SOD-1) Antibody

6641-30T each
EUR 175.2

Recombinant Human Superoxide Dismutase

7-06472 20µg Ask for price

Recombinant Human Superoxide Dismutase

7-06473 100µg Ask for price

Recombinant Human Superoxide Dismutase

7-06474 1mg Ask for price

Mouse Superoxide Dismutase 3 (SOD3) CLIA Kit

20-abx190563
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rabbit Superoxide Dismutase ELISA kit

E04S0012-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Superoxide Dismutase ELISA kit

E04S0012-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Superoxide Dismutase ELISA kit

E04S0012-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Superoxide Dismutase ELISA kit

E09S0012-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Superoxide Dismutase ELISA kit

E09S0012-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Superoxide Dismutase ELISA kit

E09S0012-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Superoxide Dismutase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Superoxide dismutase [Cu-Zn] Antibody (HRP)

20-abx107845
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Superoxide dismutase [Cu-Zn] Antibody (HRP)

20-abx108787
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Superoxide dismutase [Cu-Zn] Antibody (HRP)

20-abx108788
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Native Cactus Superoxide Dismutase, 5,000U/g

NATE-1868 1kg
EUR 440.4

Superoxide Dismutase 1 Conjugated Antibody

C49350 100ul
EUR 476.4

Cu/Zn Superoxide Dismutase, Recombinant

NATE-1143 10mg
EUR 712.8

Superoxide Dismutase 3, Extracellular (SOD3) Antibody

abx238105-100ug 100 ug
EUR 661.2

Superoxide Dismutase 3, Extracellular (SOD3) Antibody

20-abx218694
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

Superoxide Dismutase 3, Extracellular (SOD3) Antibody

20-abx103950
  • EUR 477.60
  • EUR 159.60
  • EUR 1328.40
  • EUR 644.40
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Superoxide Dismutase 3, Extracellular (SOD3) Antibody

20-abx103951
  • EUR 493.20
  • EUR 159.60
  • EUR 1362.00
  • EUR 661.20
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Superoxide Dismutase 3, Extracellular (SOD3) Antibody

20-abx103952
  • EUR 360.00
  • EUR 159.60
  • EUR 961.20
  • EUR 510.00
  • EUR 309.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Superoxide Dismutase 3, Extracellular (SOD3) Antibody

20-abx174663
  • EUR 376.80
  • EUR 944.40
  • EUR 493.20
  • EUR 184.80
  • EUR 309.60
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Superoxide Dismutase 3, Extracellular (SOD3) Antibody

20-abx174664
  • EUR 1011.60
  • EUR 526.80
  • 1 mg
  • 200 ug

Superoxide Dismutase 3, Extracellular (SOD3) Antibody

20-abx174665
  • EUR 1011.60
  • EUR 526.80
  • 1 mg
  • 200 ug

Superoxide Dismutase 3, Extracellular (SOD3) Antibody

20-abx178501
  • EUR 1362.00
  • EUR 661.20
  • 1 mg
  • 200 ug

Superoxide Dismutase 3, Extracellular (SOD3) Antibody

20-abx115903
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Superoxide Dismutase 3, Extracellular (SOD3) Antibody

abx448432-100ug 100 ug
EUR 610.8

Superoxide Dismutase 3, Extracellular (SOD3) Antibody

abx033034-400ul 400 ul
EUR 627.6

Superoxide Dismutase 3, Extracellular (SOD3) Antibody

abx033034-80l 80 µl
EUR 343.2

Superoxide Dismutase 3, Extracellular (SOD3) Antibody

20-abx129985
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
Rpd3 deficiency elevated acetylation of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) complicated subunit Sgf73 on Okay33. This acetylation website is situated inside a crucial regulatory area in Sgf73 that interacts with Ubp8 and is concerned within the activation of the Ubp8-containing histone H2B deubiquitylase complicated. Our knowledge supplies the primary world survey of acetylation in budding yeast, and suggests a wide-ranging regulatory scope of this modification. The offered knowledgeset might function an vital useful resource for the practical evaluation of lysine acetylation in eukaryotes.

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