Obstructive sleep apnea syndrome (OSAS) is a typical dysfunction with far-reaching well being implications. One of many main penalties of OSAS is an impression on neurocognitive functioning. A number of research have proven that OSAS has an adversarial impact on inductive and deductive reasoning, consideration, vigilance, studying, and reminiscence.
Neurocognitive impairment might be measured objectively with exams such because the Wechsler Grownup Intelligence Scale-Revised, the Psychomotor Vigilance Job, the Steer Clear Efficiency Take a look at, and exams of repetitive finger tapping. In youngsters, OSAS could trigger attention-deficit hyperactivity dysfunction along with behavioral issues and studying disabilities.
Danger elements for cognitive impairment embody rising age, male intercourse, apolipoprotein E ε4 allele positivity, present cigarette smoking, weight problems, hypertension, diabetes mellitus, metabolic syndrome, Down syndrome, hypothyroidism, important alcohol consumption, stroke, and using psychoactive medicines. At a mobile stage, OSAS possible causes cognitive impairment by means of intermittent hypoxia, hormonal imbalance, and/or systemic irritation, both independently or through the resultant endothelial dysfunction that happens.
Extreme daytime sleepiness ought to be measured and minimized in all research of neurocognitive impairment. Current research have used useful and structural neuroimaging to delineate the mind areas affected in sufferers with OSAS with neurocognitive dysfunction.
A typical discovering in a number of of those research is decreased hippocampal quantity. Different affected mind areas embody the frontal and parietal lobes of the mind, which present focal reductions in grey matter. These adjustments might be reversed a minimum of partially with using CPAP, which highlights the significance of early recognition and remedy of OSAS. The at present out there information on this area are fairly restricted, and extra analysis is required.
Correlating chemical sensitivity and basal gene expression reveals mechanism of motion.
Adjustments in mobile gene expression in response to small-molecule or genetic perturbations have yielded signatures that may join unknown mechanisms of motion (MoA) to ones beforehand established. We hypothesized that differential basal gene expression might be correlated with patterns of small-molecule sensitivity throughout many cell traces to light up the actions of compounds whose MoA are unknown.
To check this concept, we correlated the sensitivity patterns of 481 compounds with ∼19,000 basal transcript ranges throughout 823 completely different human most cancers cell traces and recognized selective outlier transcripts. This course of yielded many novel mechanistic insights, together with the identification of activation mechanisms, mobile transporters and direct protein targets.
We discovered that ML239, initially recognized in a phenotypic display screen for selective cytotoxicity in breast most cancers stem-like cells, most probably acts by means of activation of fatty acid desaturase 2 (FADS2). These information and analytical instruments can be found to the analysis neighborhood by means of the Most cancers Therapeutics Response Portal.
Boolean modeling in programs biology: an summary of methodology and purposes.
Mathematical modeling of organic processes gives deep insights into complicated mobile programs. Whereas quantitative and steady fashions equivalent to differential equations have been broadly used, their use is obstructed in programs whereby the data of mechanistic particulars and kinetic parameters is scarce.
However, a wealth of molecular stage qualitative information on particular person elements and interactions might be obtained from the experimental literature and high-throughput applied sciences, making qualitative approaches equivalent to Boolean community modeling extraordinarily helpful.
On this paper, we construct on our analysis to supply a strategy overview of Boolean modeling in programs biology, together with Boolean dynamic modeling of mobile networks, attractor evaluation of Boolean dynamic fashions, in addition to inferring organic regulatory mechanisms from high-throughput information utilizing Boolean fashions.
We lastly show how Boolean fashions might be utilized to carry out the structural evaluation of mobile networks. This overview goals to acquaint life science analysisers with the fundamental steps of Boolean modeling and its purposes in a number of areas of programs biology.
Heme oxygenase-1 and the vascular mattress: from molecular mechanisms to therapeutic alternatives.
Heme oxygenase-1, an enzyme degrading heme to carbon monoxide, iron, and biliverdin, has been acknowledged as enjoying a vital function in mobile protection in opposition to worrying circumstances, not solely associated to heme launch. HO-1 protects endothelial cells from apoptosis, is concerned in blood-vessel rest regulating vascular tone, attenuates inflammatory response within the vessel wall, and participates in blood-vessel formation by the use of angiogenesis and vasculogenesis.
The latter features hyperlink HO-1 not solely to cardiovascular ischemia but additionally to many different circumstances that, like growth, wound therapeutic, or most cancers, are depending on neovascularization. The goal of this complete evaluate is to handle the mechanisms of HO-1 regulation and performance in cardiovascular physiology and pathology and to show some attainable purposes of the huge data generated to date.
Current information present highly effective proof for the involvement of HO-1 within the therapeutic impact of medication utilized in cardiovascular illnesses. Novel research open the probabilities of software of HO-1 for gene and cell remedy. Subsequently, analysis in forthcoming years ought to assist to elucidate each the true function of HO-1 within the impact of medication and the medical feasibility of HO-1-based cell and gene remedy, creating the efficient therapeutic avenues for this refined antioxidant system.
Meta-analysis of genome-wide affiliation research from the CHARGE consortium identifies widespread variants related to carotid intima media thickness and plaque.
Carotid intima media thickness (cIMT) and plaque decided by ultrasonography are established measures of subclinical atherosclerosis that every predicts future heart problems occasions. We performed a meta-analysis of genome-wide affiliation information in 31,211 members of European ancestry from 9 massive research within the setting of the Cohorts for Coronary heart and Growing older Analysis in Genomic Epidemiology (CHARGE) Consortium.
We then sought further proof to help our findings amongst 11,273 people utilizing information from seven further research. Within the mixed meta-analysis, we recognized three genomic areas related to widespread carotid intima media thickness and two completely different areas related to the presence of carotid plaque (P < 5 × 10(-8)).
T-Cell Receptor Delta Chain C Region (TRDC) Antibody |
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| abx030770-80l | Abbexa | 80 µl | EUR 343.2 |
CytoSelect Cell Transformation Assay (Cell Recovery Compatible), Colorimetric, Trial Size |
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| CBA-135-T | Cell Biolabs | 24 assays | EUR 518.4 |
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Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis. |
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CytoSelect 96-Well Cell Transformation Assay (Cell Recovery Compatible, Fluorometric), Trial Size |
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| CBA-140-T | Cell Biolabs | 24 assays | EUR 547.2 |
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Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis. |
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Anti-Rat T-cell Receptor antibody |
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| STJ16100718 | St John's Laboratory | 1 mL | EUR 754.8 |
Human T- cell receptor delta chain C region, TRDC ELISA KIT |
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| ELI-16511h | Lifescience Market | 96 Tests | EUR 988.8 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (gABRD) Antibody |
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| 20-abx133715 | Abbexa |
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Gamma-Aminobutyric Acid Receptor Subunit Delta (gABRD) Antibody |
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| 20-abx112666 | Abbexa |
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Gamma-Aminobutyric Acid Receptor Subunit Delta (gABRD) Antibody |
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| abx034314-400ul | Abbexa | 400 ul | EUR 627.6 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (gABRD) Antibody |
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| abx034314-80l | Abbexa | 80 µl | EUR 343.2 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (gABRD) Antibody |
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| abx233287-100ug | Abbexa | 100 ug | EUR 610.8 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody |
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| abx444998-100ug | Abbexa | 100 ug | EUR 627.6 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (GABRD) Antibody |
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| 20-abx328382 | Abbexa |
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CytoSelect 24-Well Cell Migration Assay (8 µm, Colorimetric Format), Trial Size |
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| CBA-100-T | Cell Biolabs | 4 assays | EUR 358.8 |
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Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines. |
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CytoSelect 24-Well Cell Migration Assay (8 µm, Fluorometric Format), Trial Size |
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| CBA-101-T | Cell Biolabs | 4 assays | EUR 358.8 |
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Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines. |
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CytoSelect 24-Well Cell Migration Assay (5 µm, Fluorometric Format), Trial Size |
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| CBA-102-T | Cell Biolabs | 4 assays | EUR 358.8 |
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Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 5 µm pore size is ideal for monocytes / macrophages. |
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CytoSelect 24-Well Cell Migration Assay (3 µm, Fluorometric Format), Trial Size |
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| CBA-103-T | Cell Biolabs | 4 assays | EUR 358.8 |
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Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 3 µm pore size is best for the smallest cells including neutrophils and other leukocytes. |
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CytoSelect 24-Well Cell Invasion Assay (Basement Membrane, Colorimetric Format), Trial Size |
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| CBA-110-T | Cell Biolabs | 4 assays | EUR 386.4 |
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Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 24-well plates on either a standard microplate reader or a fluorescence plate reader. Inserts are precoated on the top of the membrane with ECM matrix gel (basement membrane), a protein mix isolated from EHS tumor cells. |
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CytoSelect 24-Well Cell Invasion Assay (Basement Membrane, Fluorometric Format), Trial Size |
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| CBA-111-T | Cell Biolabs | 4 assays | EUR 386.4 |
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Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 24-well plates on either a standard microplate reader or a fluorescence plate reader. Inserts are precoated on the top of the membrane with ECM matrix gel (basement membrane), a protein mix isolated from EHS tumor cells. |
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CytoSelect 96-Well Cell Transformation Assay (Soft Agar Colony Formation), Trial Size |
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| CBA-130-T | Cell Biolabs | 24 assays | EUR 463.2 |
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Description: Our CytoSelect 96-Well Cell Transformation Assay (Soft Agar Colony Formation) is suitable for measuring cell transformation where no downstream analysis is required. Cells are incubated in a semisolid agar medium for 7-8 days. The cells are then solubilized, lysed and detected using the included fluorescent dye in a fluorometric plate reader. |
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T-Cell Receptor Gamma-2 Chain C Region (TRGC2) Antibody |
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| abx030771-400ul | Abbexa | 400 ul | EUR 627.6 |
T-Cell Receptor Gamma-2 Chain C Region (TRGC2) Antibody |
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| abx030771-80l | Abbexa | 80 µl | EUR 343.2 |
Human T-cell receptor T3 gamma chain(CD3G)ELISA Kit |
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| YLA4500HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
Human T-cell receptor T3 gamma chain(CD3G)ELISA Kit |
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| YLA4500HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
p38 gamma/delta Antibody |
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| DF10341 | Affbiotech | 200ul | EUR 420 |
gamma delta TCR antibody |
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| 10R-6534 | Fitzgerald | 100 ug | EUR 217.2 |
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Description: Armenian Hamster monoclonal gamma delta TCR antibody |
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gamma delta TCR antibody |
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| 10R-6692 | Fitzgerald | 100 ug | EUR 249.6 |
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Description: Mouse monoclonal gamma delta TCR antibody |
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TCR gamma delta antibody |
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| 10R-8120 | Fitzgerald | 100 ug | EUR 548.4 |
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Description: Mouse monoclonal T Cell Receptor gamma delta antibody |
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TCR gamma / delta Antibody |
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| abx139895-01mg | Abbexa | 0.1 mg | EUR 376.8 |
TCR gamma / delta Antibody |
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| abx140352-01mg | Abbexa | 0.1 mg | EUR 427.2 |
TCR gamma / delta Antibody |
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| abx140353-01mg | Abbexa | 0.1 mg | EUR 427.2 |
TCR gamma / delta Antibody |
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| 20-abx200993 | Abbexa |
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CaMK2-beta / gamma / delta Cell ELISA Kit |
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| abx595083-96tests | Abbexa | 96 tests | EUR 764.4 |
T-Pro Stacking Buffer |
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| JB03-C002 | T-Pro Biotechnology | 500ml/BT | EUR 182.4 |
T-Pro MycoClean spray |
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| JT90-R002 | T-Pro Biotechnology | 500ml/BT | EUR 172.8 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (Biotin) |
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| abx442956-100ug | Abbexa | 100 ug | EUR 693.6 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (FITC) |
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| abx443236-100ug | Abbexa | 100 ug | EUR 678 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (HRP) |
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| abx443517-100ug | Abbexa | 100 ug | EUR 678 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (PerCP) |
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| abx444079-100ug | Abbexa | 100 ug | EUR 693.6 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (RPE) |
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| abx444360-100ug | Abbexa | 100 ug | EUR 693.6 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (Streptavidin) |
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| abx444641-100ug | Abbexa | 100 ug | EUR 693.6 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (ALP) |
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| abx442395-100ug | Abbexa | 100 ug | EUR 693.6 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (APC) |
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| abx442676-100ug | Abbexa | 100 ug | EUR 693.6 |
p38 gamma/delta Blocking Peptide |
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| DF10341-BP | Affbiotech | 1mg | EUR 234 |
CaMKII beta/ gamma/ delta Antibody |
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| AF6434 | Affbiotech | 200ul | EUR 420 |
CaMK2 beta/gamma/delta antibody |
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| 70R-32640 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Rabbit polyclonal CaMK2 beta/gamma/delta antibody |
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gamma delta TCR antibody (FITC) |
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| 61R-1138 | Fitzgerald | 100 ug | EUR 379.2 |
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Description: Armenian Hamster monoclonal gamma delta TCR antibody (FITC) |
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gamma delta TCR antibody (FITC) |
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| 61R-1144 | Fitzgerald | 50 ug | EUR 198 |
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Description: Mouse monoclonal gamma delta TCR antibody (FITC) |
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gamma delta TCR antibody (PE) |
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| 61R-1342 | Fitzgerald | 100 ug | EUR 360 |
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Description: Armenian Hamster monoclonal gamma delta TCR antibody (PE) |
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gamma delta TCR antibody (PE) |
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| 61R-1440 | Fitzgerald | 100 tests | EUR 483.6 |
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Description: Mouse monoclonal gamma delta TCR antibody (PE) |
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gamma delta TCR antibody (biotin) |
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| 61R-1593 | Fitzgerald | 100 ug | EUR 379.2 |
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Description: Armenian Hamster monoclonal gamma delta TCR antibody (biotin) |
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gamma delta TCR antibody (allophycocyanin) |
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| 61R-1772 | Fitzgerald | 100 ug | EUR 360 |
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Description: Armenian Hamster monoclonal gamma delta TCR antibody (allophycocyanin) |
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CaMKIIBeta/Gamma/Delta Polyclonal Antibody |
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| ABP56647-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of CaMKIIBeta/?/? from Human, Mouse, Rat. This CaMKIIBeta/?/? antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human CaMKII?/?/? around the non-phosphorylation site of T287 |
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CaMKIIBeta/Gamma/Delta Polyclonal Antibody |
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| ABP56647-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of CaMKIIBeta/?/? from Human, Mouse, Rat. This CaMKIIBeta/?/? antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human CaMKII?/?/? around the non-phosphorylation site of T287 |
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CaMKIIBeta/Gamma/Delta Polyclonal Antibody |
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| ABP56647-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of CaMKIIBeta/?/? from Human, Mouse, Rat. This CaMKIIBeta/?/? antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human CaMKII?/?/? around the non-phosphorylation site of T287 |
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TCR gamma / delta Antibody (PE) |
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| abx139901-01mg | Abbexa | 0.1 mg | EUR 410.4 |
TCR gamma / delta Antibody (FITC) |
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| abx140379-100tests | Abbexa | 100 tests | EUR 510 |
TCR gamma / delta Antibody (PE) |
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| abx140380-100tests | Abbexa | 100 tests | EUR 577.2 |
CaMK2 beta / gamma / delta Antibody |
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| abx011680-100ug | Abbexa | 100 ug | EUR 526.8 |
CaMK2- beta/gamma/delta Antibody |
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| ABF6434 | Lifescience Market | 100 ug | EUR 525.6 |
TCR gamma / delta Antibody (APC) |
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| 20-abx200986 | Abbexa |
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TCR gamma / delta Antibody (Biotin) |
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| 20-abx200987 | Abbexa |
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TCR gamma / delta Antibody (FITC) |
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| 20-abx200989 | Abbexa |
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TCR gamma / delta Antibody (PE) |
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| 20-abx200990 | Abbexa |
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TCR gamma / delta Antibody (PerCP) |
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| 20-abx200991 | Abbexa |
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T-Complex Protein 1 Subunit Delta (TCP1 delta) Antibody |
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| 20-abx141878 | Abbexa |
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CaMK2-beta / gamma / delta (pT287) Cell ELISA Kit |
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| abx596064-296tests | Abbexa | 2 × 96 tests | EUR 848.4 |
Anti-T-Cell receptor antibody |
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| STJ16100480 | St John's Laboratory | 100 µg | EUR 487.2 |
T-Pro EZ Gel Solution 8% |
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| JB02-B008M | T-Pro Biotechnology | 500ml/BT | EUR 266.4 |
T-Pro EZ Gel Solution 8% |
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| JB02-B008S | T-Pro Biotechnology | 100ml/BT | EUR 162 |
T-Pro EZ Gel Solution 10% |
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| JB02-B010M | T-Pro Biotechnology | 500ml/BT | EUR 266.4 |
T-Pro EZ Gel Solution 10% |
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| JB02-B010S | T-Pro Biotechnology | 100ml/BT | EUR 162 |
T-Pro EZ Gel Solution 12% |
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| JB02-B012M | T-Pro Biotechnology | 500ml/BT | EUR 266.4 |
T-Pro EZ Gel Solution 12% |
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| JB02-B012S | T-Pro Biotechnology | 100ml/BT | EUR 162 |
T-Pro EZ Gel Solution 15% |
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| JB02-B015M | T-Pro Biotechnology | 500ml/BT | EUR 266.4 |
T-Pro EZ Gel Solution 15% |
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| JB02-B015S | T-Pro Biotechnology | 100ml/BT | EUR 162 |
T-Pro Separating or Resolving Buffer |
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| JB03-C001 | T-Pro Biotechnology | 500ml/BT | EUR 182.4 |
T-Pro BCA Protein Assay kit |
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| JB04-D001 | T-Pro Biotechnology | 500assay/KIT | EUR 244.8 |
T-Pro Transfer Blotting buffer (10X) |
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| JB08-H001 | T-Pro Biotechnology | 500ml/BT | EUR 162 |
T-Pro Western Blot Stripping Reagent |
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| JB11-K002 | T-Pro Biotechnology | 500ml/BT | EUR 213.6 |
T-Pro Aqua EZ Clean (M) |
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| JT90-R001M | T-Pro Biotechnology | 500ml/BT | EUR 398.4 |
T-Pro Aqua EZ Clean (S) |
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| JT90-R001S | T-Pro Biotechnology | 100ml/BT | EUR 181.2 |
T-Pro EZ stain Gel solution |
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| JT90-R005M | T-Pro Biotechnology | 500ml/BT | EUR 224.4 |
T-Pro EZ stain Gel solution |
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| JT90-R005S | T-Pro Biotechnology | 100ml/BT | EUR 151.2 |
T-Pro P-Fect Transfection Reagent |
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| JT97-N005M | T-Pro Biotechnology | 1.0ml/vial | EUR 266.4 |
T-Pro Plasmid Mini Kit (100) |
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| RB94-YPD100 | T-Pro Biotechnology | 100preps/Kit | EUR 193.2 |
T-Pro Plasmid Mini Kit (250) |
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| RB94-YPD250 | T-Pro Biotechnology | 250preps/Kit | EUR 266.4 |
T-Pro Plasmid Midi Kit (20) |
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| RB94-YPI020 | T-Pro Biotechnology | 20preps/Kit | EUR 255.6 |
T-Pro Plasmid Maxi Kit (10) |
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| RB94-YPM010 | T-Pro Biotechnology | 10preps/Kit | EUR 266.4 |
Opioid Receptor-delta Cell ELISA Kit |
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| abx595435-96tests | Abbexa | 96 tests | EUR 764.4 |
Human T- cell receptor gamma chain C region 1, TRGC1 ELISA KIT |
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| ELI-51630h | Lifescience Market | 96 Tests | EUR 988.8 |
Human T- cell receptor gamma- 2 chain C region, TRGC2 ELISA KIT |
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| ELI-28913h | Lifescience Market | 96 Tests | EUR 988.8 |
Human Gamma-Aminobutyric Acid Receptor Subunit Delta (GABRD) ELISA Kit |
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| abx387467-96tests | Abbexa | 96 tests | EUR 1093.2 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (ATTO 390) |
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| abx440147-100ug | Abbexa | 100 ug | EUR 693.6 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (ATTO 488) |
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| abx440428-100ug | Abbexa | 100 ug | EUR 693.6 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (ATTO 565) |
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| abx440709-100ug | Abbexa | 100 ug | EUR 693.6 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (ATTO 594) |
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| abx440990-100ug | Abbexa | 100 ug | EUR 693.6 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (ATTO 633) |
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| abx441271-100ug | Abbexa | 100 ug | EUR 693.6 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (ATTO 655) |
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| abx441552-100ug | Abbexa | 100 ug | EUR 693.6 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (ATTO 680) |
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| abx441833-100ug | Abbexa | 100 ug | EUR 693.6 |
Gamma-Aminobutyric Acid Receptor Subunit Delta (Gabrd) Antibody (ATTO 700) |
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| abx442114-100ug | Abbexa | 100 ug | EUR 693.6 |
Anti-Rat T-cell Receptor & Epithelial Tumours antibody |
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| STJ16100721 | St John's Laboratory | 1 mL | EUR 754.8 |
T-Cell Surface Glycoprotein CD3 Delta Chain (CD3D) Antibody |
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| 20-abx133546 | Abbexa |
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T-Cell Surface Glycoprotein CD3 Delta Chain (CD3D) Antibody |
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| 20-abx001150 | Abbexa |
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T-Cell Surface Glycoprotein CD3 Delta Chain (CD3D) Antibody |
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| 20-abx009478 | Abbexa |
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T-Cell Surface Glycoprotein CD3 Delta Chain (CD3D) Antibody |
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| 20-abx320335 | Abbexa |
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T-Pro BCA Protein Assay Reagent A |
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| JB04-D001A | T-Pro Biotechnology | 500ml/BT | EUR 204 |
T-Pro BCA Protein Assay Reagent B |
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| JB04-D001B | T-Pro Biotechnology | 12ml/BT | EUR 140.4 |
T-Pro Bradford Protein Assay kit(1X) |
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| JB04-D002 | T-Pro Biotechnology | 500ml/BT | EUR 193.2 |
T-Pro Fast Blocking Buffer (in PBS) |
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| JK92-W001 | T-Pro Biotechnology | 500ml/BT | EUR 224.4 |
T-Pro Fast Blocking Buffer (in TBS) |
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| JK92-W002 | T-Pro Biotechnology | 500ml/BT | EUR 224.4 |
T-Pro Genomic DNA Midi Kit (20) |
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| RB94-NGM020 | T-Pro Biotechnology | 20preps/kit | EUR 266.4 |
T-Pro Genomic DNA Mini Kit (100) |
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| RB94-NGS100 | T-Pro Biotechnology | 100preps/kit | EUR 255.6 |
Custom production of antibodies in 5 Rats using customer supplied antigen (std 63 days protocol) |
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| RAT-5 | Alpha Diagnostics | 1 | EUR 1365.6 |
Recombinant T-Cell Surface Glycoprotein CD3 Gamma (CD3g) |
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| 4-RPD118Hu01 | Cloud-Clone |
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Description: Recombinant Human T-Cell Surface Glycoprotein CD3 Gamma expressed in: E.coli |
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CytoSelect 24-Well Wound Healing Assay, Trial Size |
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| CBA-120-T | Cell Biolabs | 6 assays | EUR 428.4 |
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Description: Traditionally scratch assays have been used to study cell migration, cell proliferation and wound healing. However, these assays lack a consistently defined wound gap and can result in high inter-sample variation. Our CytoSelect 24-Well Wound Healing Assay provides a much more consistent method to measure cell migration across a wound field gap in vitro. Proprietary inserts generate a consistent 0.9mm wound gap between the cells. Cells may then be treated or monitored for proliferation or migration across the wound field by imaging samples at fixed time points or by time-lapse microscopy. |
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CytoSelect 96-Well In Vitro Tumor Sensitivity Assay (Soft Agar Colony Formation), Trial Size |
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| CBA-150-T | Cell Biolabs | 24 assays | EUR 483.6 |
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Description: Traditionally, the soft agar colony formation assay has been used to monitor anchorage-independent growth. Cells proliferate for 3-4 weeks in a semisolid culture medium, followed by tedious manual counting of colonies. Our CytoSelect 96-Well In Vitro Tumor Sensitivity Assay provides a stringent, anchorage-independent model for chemosenstivity testing and screening of potential anticancer drugs. After just 6-8 days, cell colonies are quantified using a standard colorimetric microplate reader. |
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CytoSelect 96-Well Phagocytosis Assay(Zymosan Substrate), Trial Size |
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| CBA-224-T | Cell Biolabs | 20 assays | EUR 463.2 |
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Description: Phagocytosis can be assayed by measuring the engulfment of a cell "substrate". However, traditional assays require tedious cell counting under a microscope. Our CytoSelect 96-Well Phagocytosis Assay, Zymosan Substrate provides a more accurate, user-friendly, high-throughput alternative to the standard phagocytosis assay. The assay may be adapted for use with 24-well or 48-well plates. |
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96-Well Cellular Senescence Assay Kit (SA-?-gal Activity, Fluorometric Format), Trial Size |
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| CBA-231-T | Cell Biolabs | 24 assays | EUR 414 |
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Description: Our Cellular Senescence Activity Assay provides an efficient method to measure Senescence Associated (SA) ß-galactosidase activity. SA-ß-Gal catalyzes the hydrolysis of X-gal, which produces a blue color in senescent cells. Quantify senescence using a fluorescence plate reader. |
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GFP ELISA Kit, Trial Size |
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| AKR-121-T | Cell Biolabs | 32 assays | EUR 470.4 |
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Description: Most imaging studies of rGFP are qualitative, and quantitation by FACS is time-consuming and expensive. Our GFP ELISA Kit measures green fluorescent protein in a standard microplate reader. Assay is sensitive to 30 pg/mL. |
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OxiSelect Nitrotyrosine ELISA Kit, Trial Size |
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| STA-305-T | Cell Biolabs | 32 assays | EUR 505.2 |
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Description: Nitric oxide influences a variety of biological processes including cell proliferation, apoptosis, neurotoxicity and extracellular matrix remodeling. Nitric oxide reacts with superoxide to form peroxynitrite, which in turn nitrates tyrosine residues in proteins. Nitrotyrosine therefore serves as a marker for peroxynitrite action in a variety of disease states and in conditions of cellular damage and oxidative stress. Our OxiSelect Nitrotyrosine ELISA Kit provides a sensitive method to measure the formation of 3-nitrotyrosine in proteins. |
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OxiSelect Protein Carbonyl Fluorometric Assay, Trial Size |
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| STA-307-T | Cell Biolabs | 20 assays | EUR 421.2 |
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Description: The most common products of protein oxidation in biological samples are the carbonyl derivatives of proline, lysine, arginine and threonine residues. Such derivatives are chemically stable and serve as markers for oxidative stress in most types of reactive oxygen species. Our OxiSelect Protein Carbonyl Fluorometric Assay Kit provides a rapid, efficient method for the detection of protein carbonyl residues. The fluorescence plate-based format provides a convenient system for direct measurement of protein carbonyl content. |
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OxiSelect Protein Carbonyl Immunoblot Kit, Trial Size |
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| STA-308-T | Cell Biolabs | 4 blots | EUR 316.8 |
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Description: The most common products of protein oxidation in biological samples are the carbonyl derivatives of proline, lysine, arginine and threonine residues. Such derivatives are chemically stable and serve as markers for oxidative stress in most types of reactive oxygen species. Our OxiSelect Protein Carbonyl Immunoblot Kit provides a rapid, efficient method for the detection of protein carbonyl residues. The immunoblot format provides a convenient way to compare oxidized and non-oxidized protein fingerprints. |
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OxiSelect Protein Carbonyl ELISA Kit, Trial Size |
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| STA-310-T | Cell Biolabs | 32 assays | EUR 505.2 |
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Description: The most common products of protein oxidation in biological samples are the carbonyl derivatives of proline, lysine, arginine and threonine residues. Such derivatives are chemically stable and serve as markers for oxidative stress in most types of reactive oxygen species. Our OxiSelect Protein Carbonyl ELISA Kit provides a rapid, efficient method for the detection of protein carbonyl residues. The ELISA format is perfect for higher throughput and high sensitivity; we have eliminated concentration and precipitation steps allowing greater sample retention. |
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OxiSelect Total Glutathione (GSSG/GSH) Assay Kit, Trial Size |
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| STA-312-T | Cell Biolabs | 20 assays | EUR 338.4 |
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Description: The OxiSelect Total Glutathione Assay Kit is a quantitative assay for measuring the total glutathione content within a sample (GSH/GSSG). Glutathione Reductase reduces oxidized glutathione (GSSG) to reduced glutathione (GSH) in the presence of NADPH. Subsequently, the chromogen reacts with the thiol group of GSH to produce a colored compound that absorbs at 405 nm. The total glutathione content in unknown samples is determined by comparison with the predetermined glutathione standard curve. The rate of chromophore production is proportional to the concentration of glutathione within the sample. The rate can be determined from the absorbance change over time. Metaphosphoric acid is provided to remove interfering proteins or enzymes from samples. |
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OxiSelect Oxidative DNA Damage ELISA Kit (8-OHdG Quantitation), Trial Size |
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| STA-320-T | Cell Biolabs | 32 assays | EUR 609.6 |
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Description: Among numerous types of oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG) is a ubiquitous marker of oxidative stress. 8-OHdG, one of the byproducts of oxidative DNA damage, is physiologically formed and enhanced by chemical carcinogens. Our OxiSelect Oxidative DNA Damage ELISA Kit (8-hydroxydeoxyguanosine assay) provides a powerful method for rapid, sensitive quantitation of 8-OHdG in DNA samples. |
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OxiSelect DNA Double Strand Break (DSB) Staining Kit, Trial Size |
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| STA-321-T | Cell Biolabs | 20 assays | EUR 421.2 |
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Description: Double-strand breaks (DSB) in DNA are among the most dangerous types of DNA damage occuring within cells. One of the earliest cellular responses to double-strand breaks is the phosphorylation of a histone variant, H2AX, at the sites of DNA damage. Within seconds Ser139 is phosphorylated when DSBs are induced in mammalian cells. Phosphorylation of this serine residue causes chromatin condensation and appears to play a critical role in the recruitment of repair or damage-signaling factors to the DNA damage sites. The OxiSelect DNA Double-Strand Break Staining Kit provides an easy-to-use method for detecting the presence of DSBs in cells cultured in microtiter plates. Double strand breaks can be detected in just a few hours by immunofluorescence staining of the phosphorylated histone H2AX. |
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OxiSelect UV-Induced DNA Damage ELISA Kit (CPD Quantitation), Trial Size |
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| STA-322-T | Cell Biolabs | 32 assays | EUR 421.2 |
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Description: Our OxiSelect UV-Induced DNA Damage ELISA Kit measures the formation of cyclobutane pyrimidine dimers (CPD) in DNA isolated from cells or tissues. Standards or unknown DNA samples are first heat denatured before adsorbed onto a 96-well DNA binding plate. The sample or standard are then probed with an anti-CPD antibody, followed by an HRP conjugated secondary antibody. |
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OxiSelect UV-Induced DNA Damage ELISA Kit (6-4PP Quantitation), Trial Size |
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| STA-323-T | Cell Biolabs | 32 assays | EUR 421.2 |
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Description: Our OxiSelect UV-Induced DNA Damage ELISA Kit measures 6-4PP formation in DNA isolated from cells or tissue. Standards or unknown DNA samples are first heat denatured before adsorbed onto a 96-well DNA binding plate. The sample or standard is then probed with an anti-6-4PP antibody, followed by an HRP conjugated secondary antibody. |
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OxiSelect Oxidative DNA Damage Quantitation Kit (AP Sites), Trial Size |
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| STA-324-T | Cell Biolabs | 10 assays | EUR 498 |
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Description: DNA damage can manifest in the formation of apurinic or apyrimidinic (AP or abasic) sites. Such spontaneous base loss in mammalian cells has been estimated at between 50,000 and 200,000 sites per day. Unrepaired abasic sites can inhibit transcription and may be mutagenic. Our OxiSelect Oxidative DNA Damage Quantitation Kit provides a simple, user-friendly method for the quantitaiton DNA damage in the form of abasic sites. The assay uses an Aldehyde Reactive Probe (ARP) to specifically react with an aldehyde group on the open ring of the AP site. This allows the AP site to be labeled with Biotin, followed by detection with Streptavidin-Enzyme conjugate. |
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OxiSelect Oxidative RNA Damage ELISA Kit (8-OHG Quantitation), Trial Size |
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| STA-325-T | Cell Biolabs | 32 assays | EUR 609.6 |
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Description: Recently oxidative RNA damage has been described in conjunction with a wide variety of neurological diseases including Alzheimer?s disease, Parkinson?s disease, Dementia with Lewy Bodies, prion disease, and subacute sclerosing panencephalitis. We have developed an easy-to-use ELISA for the detection of the most common marker of RNA damage: 8-hydroxyguanosine (8-OHG). |
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OxiSelect Cellular UV-Induced DNA Damage ELISA Kit (CPD), Trial Size |
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| STA-326-T | Cell Biolabs | 32 assays | EUR 421.2 |
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Description: Our OxiSelect Cellular UV-Induced DNA Damage ELISA Kit mesaures the formation of cyclobutane pyrimidine dimers (CPD) in intact cells. Cells are first seeded in a 96-well tissue culture plate. Wells are then UV irradiated to induce DNA damage. After fixation and denaturation, cells containing the DNA lesions are probed with an anti-CPD antibody, followed by an HRP conjugated secondary antibody. |
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OxiSelect Cellular UV-Induced DNA Damage Staining Kit (CPD), Trial Size |
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| STA-327-T | Cell Biolabs | 32 assays | EUR 421.2 |
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Description: Our OxiSelect Cellular UV-Induced DNA Damage Staining Kit measures the formation of cyclobutane pyrimidine dimers (CPD) by immunofluorescence. Cells are first seeded in a 96-well tissue culture plate. Wells are then UV irradiated to induce DNA damage. After fixation and denaturation, cells containing the DNA lesions are probed with an anti-CPD antibody, followed by a FITC conjugated secondary antibody. The unbound secondary antibody is removed during a wash step, and stained cells can then be visualized with a fluorescence microscope. |
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OxiSelect Cellular UV-Induced DNA Damage ELISA Kit (6-4PP), Trial Size |
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| STA-328-T | Cell Biolabs | 32 assays | EUR 421.2 |
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Description: Our OxiSelect Cellular UV-Induced DNA Damage ELISA Kit measures the formation of 6-4PP in intact cells in a 96-well ELISA plate-based format. Cells are first seeded in a 96-well tissue culture plate. Wells are then UV irradiated to induce DNA damage. After fixation and denaturation, cells containing the DNA lesions are probed with an anti-6-4PP antibody, followed by an HRP conjugated secondary antibody. |
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The related SNPs mapped in or close to genes associated to mobile signaling, lipid metabolism and blood stress homeostasis, and two of the areas have been related to coronary artery illness (P < 0.006) within the Coronary Artery Illness Genome-Extensive Replication and Meta-Evaluation (CARDIoGRAM) consortium. Our findings could present new perception into pathways resulting in subclinical atherosclerosis and subsequent cardiovascular occasions.