PTEN function: how normal cells control it and tumour cells lose it.

PTEN function: how normal cells control it and tumour cells lose it.

The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour suppressor is a PI (phosphoinositide) 3-phosphatase that may inhibit mobile proliferation, survival and progress by inactivating PI 3-kinase-dependent signalling. It additionally suppresses mobile motility via mechanisms which may be partially unbiased of phosphatase … Read More

The consensus coding sequences of human breast and colorectal cancers.

The consensus coding sequences of human breast and colorectal cancers.

The elucidation of the human genome sequence has made it potential to ascertain genetic alterations in cancers in unprecedented component. To start out a scientific analysis of such alterations, we determined the sequence of well-annotated human protein-coding genes in two … Read More