Converging lines of research suggest that the hippocampal complex (HC) may have a role in the pathophysiology of major depressive disorder (MDD). Although postmortem studies show little cellular death in the HC of depressed patients, animal studies suggest that elevated glucocorticoid levels associated with … Read More
It has been 20 years since investigators discovered the hyperlink between the Drosophila wingless (Wg) gene and the vertebrate oncogene int-1, thus establishing the family of signaling proteins known as Wnts. Given that inception of the Wnt signaling space, there … Read More
The p53 tumor suppressor protein has well-established roles in monitoring numerous forms of stress alerts by activating particular transcriptional targets that management cell cycle arrest and apoptosis, though some actions are additionally mediated in a transcription-independent method. Right here, we … Read More
A succession of technological advances over the previous decade have enabled analysisers to chart maps of histone modifications and associated chromatin constructions with growing accuracy, comprehensiveness and throughput. The ensuing information units spotlight the interaction between chromatin and genome perform, dynamic variations in … Read More
Oxidative stress is usually outlined as an imbalance of pro-oxidants and antioxidants, which could be quantified in people because the redox state of plasma GSH/GSSG. Plasma GSH redox in people turns into oxidized with age, in response to oxidative stress … Read More
The 90 kDa ribosomal S6 kinase (RSK) household of proteins is a gaggle of extremely conserved Ser/Thr kinases that regulate various mobile processes, resembling cell progress, cell motility, cell survival and cell proliferation. RSKs are downstream effectors of the Ras-extramobile signal-regulated kinase (ERK)/mitogen-activated … Read More
Bioactive compounds might be helpful analysis instruments and drug leads, however it’s usually tough to establish their mechanism of motion or mobile goal. Right here we examine the potential for integration of chemical-genetic and genetic interplay information to disclose details about the pathways and targets of … Read More
Endogenously produced pro-oxidant reactive species are important to life, being concerned in a number of organic features. Nevertheless, when overproduced (e.g. attributable to exogenous stimulation), or when the degrees of antioxidants grow to be severely depleted, these reactive species grow … Read More
The elucidation of the human genome sequence has made it potential to ascertain genetic alterations in cancers in unprecedented component. To start out a scientific analysis of such alterations, we determined the sequence of well-annotated human protein-coding genes in two … Read More