Concern is an adaptive element of the acute “stress” response to potentially-dangerous (exterior and inner) stimuli which threaten to perturb homeostasis. Nevertheless, when disproportional in depth, power and/or irreversible, or not related to any real threat, it could be symptomatic of a debilitating anxious state: for instance, social phobia, panic assaults or generalized nervousness dysfunction.
In view of the significance of guaranteeing an acceptable emotional response to aversive occasions, it isn’t shocking {that a} variety of mechanisms are concerned within the induction and inhibition of anxious states. Other than standard neurotransmitters, corresponding to monoamines, gamma-amino-butyric acid (GABA) and glutamate, many different modulators have been implicated, together with: adenosine, cannabinoids, quite a few neuropeptides, hormones, neurotrophins, cytokines and a number of other mobile mediators.
Accordingly, although benzodiazepines (which reinforce transmission at GABA(A) receptors), serotonin (5-HT)(1A) receptor agonists and 5-HT reuptake inhibitors are presently the precept medication employed within the administration of hysteria issues, there may be appreciable scope for the event of different therapies.
Along with mobile, anatomical and neurochemical methods, behavioral fashions are indispensable for the characterization of anxious states and their modulation. Amongst numerous paradigms, battle procedures–in which topics expertise opposing impulses of need and fear–are of especial conceptual and therapeutic pertinence.
For instance, within the Vogel Battle Check (VCT), the power of medicine to launch punishment-suppressed consuming conduct is evaluated. In reviewing the neurobiology of anxious states, the current article focuses particularly upon: the multifarious and sophisticated roles of particular person modulators, usually as a perform of the particular receptor sort and neuronal substrate concerned of their actions; novel targets for the administration of hysteria issues; the affect of neurotransmitters and different brokers upon efficiency within the VCT; knowledge acquired from complementary pharmacological and genetic methods and, lastly, a number of open questions prone to orientate future experimental- and clinical-analysis.
MUC16 Antibody |
CSB-PA899266-100ul |
Cusabio |
100ul |
EUR 316 |
|
Description: A polyclonal antibody against MUC16. Recognizes MUC16 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF;IF:1:100-1:500 |
MUC16 Antibody |
49089-100ul |
SAB |
100ul |
EUR 333 |
MUC16 Antibody |
49089-50ul |
SAB |
50ul |
EUR 239 |
MUC16 Antibody |
49090-100ul |
SAB |
100ul |
EUR 333 |
MUC16 Antibody |
49090-50ul |
SAB |
50ul |
EUR 239 |
MUC16 Antibody |
DF7989 |
Affbiotech |
200ul |
EUR 304 |
Description: MUC16 Antibody detects endogenous levels of total MUC16. |
MUC16 antibody |
70R-15295 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal MUC16 antibody |
MUC16 antibody |
70R-32038 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal MUC16 antibody |
MUC16 Polyclonal Antibody |
A54125 |
EpiGentek |
100 µg |
EUR 570.55 |
Description: The best epigenetics products |
MUC16,CA125 Antibody |
abx235429-100ug |
Abbexa |
100 ug |
EUR 551 |
|
MUC16,CA125 Antibody |
abx235430-100ug |
Abbexa |
100 ug |
EUR 509 |
|
Anti-MUC16 antibody |
STJ112045 |
St John's Laboratory |
100 µl |
EUR 277 |
Description: This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. |
MUC16 Conjugated Antibody |
C49089 |
SAB |
100ul |
EUR 397 |
MUC16 Conjugated Antibody |
C37173 |
SAB |
100ul |
EUR 397 |
Anti-MUC16 Antibody |
A1293-100 |
Biovision |
|
EUR 370 |
Anti-MUC16 Antibody |
A1391-100 |
Biovision |
|
EUR 370 |
MUC16 antibody (HRP) |
60R-1720 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal MUC16 antibody (HRP) |
MUC16 antibody (FITC) |
60R-1721 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal MUC16 antibody (FITC) |
MUC16 antibody (biotin) |
60R-1722 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal MUC16 antibody (biotin) |
MUC16 siRNA |
20-abx925014 |
Abbexa |
|
|
|
MUC16 Peptide |
42-562P |
ProSci |
0.1 mg |
EUR 338 |
Description: (CT) MUC16 Peptide |
Muc16 Peptide |
42-868P |
ProSci |
0.1 mg |
EUR 338 |
Description: (IN) Muc16 (Rat) peptide |
Mucin 16 (MUC16) Antibody |
abx036002-100ug |
Abbexa |
100 ug |
EUR 391 |
|
Monoclonal MUC16 / CA125 Antibody |
AMM01977G |
Leading Biology |
0.05mg |
EUR 484 |
Description: A Monoclonal antibody against Human MUC16 / CA125. The antibodies are raised in Mouse. This antibody is applicable in IHC-P, E |
MUC16 Antibody, HRP conjugated |
1-CSB-PA10657B0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against MUC16. Recognizes MUC16 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
MUC16 Antibody, FITC conjugated |
1-CSB-PA10657C0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against MUC16. Recognizes MUC16 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
MUC16 Antibody, Biotin conjugated |
1-CSB-PA10657D0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against MUC16. Recognizes MUC16 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
anti- MUC16,CA125 antibody |
FNab05429 |
FN Test |
100µg |
EUR 585 |
|
Description: Antibody raised against MUC16,CA125 |
anti- MUC16,CA125 antibody |
FNab05430 |
FN Test |
100µg |
EUR 548.75 |
|
Description: Antibody raised against MUC16,CA125 |
MUC16 Rabbit pAb |
A10005-100ul |
Abclonal |
100 ul |
EUR 308 |
MUC16 Rabbit pAb |
A10005-200ul |
Abclonal |
200 ul |
EUR 459 |
MUC16 Rabbit pAb |
A10005-20ul |
Abclonal |
20 ul |
EUR 183 |
MUC16 Rabbit pAb |
A10005-50ul |
Abclonal |
50 ul |
EUR 223 |
MUC16 Blocking Peptide |
20-abx162594 |
Abbexa |
|
|
|
MUC16 Blocking Peptide |
DF7989-BP |
Affbiotech |
1mg |
EUR 195 |
Anti-CA125 / MUC16 Monoclonal Antibody |
M01641-1 |
BosterBio |
100ug |
EUR 397 |
Description: Rabbit Monoclonal CA125 / MUC16 Antibody. Validated in IHC and tested in Human. |
MUC16 Polyclonal Antibody, HRP Conjugated |
A54126 |
EpiGentek |
100 µg |
EUR 570.55 |
Description: kits suitable for this type of research |
MUC16 Polyclonal Antibody, FITC Conjugated |
A54127 |
EpiGentek |
100 µg |
EUR 570.55 |
Description: fast delivery possible |
MUC16 Polyclonal Antibody, Biotin Conjugated |
A54128 |
EpiGentek |
100 µg |
EUR 570.55 |
Description: reagents widely cited |
Anti-MUC16/Ca125 Rabbit Monoclonal Antibody |
M01641 |
BosterBio |
100ug/vial |
EUR 397 |
Description: Rabbit Monoclonal MUC16/Ca125 Antibody. Validated in Flow Cytometry, IF, ICC, WB and tested in Human. |
Polyclonal MUC16 / CA125 Antibody (aa13311-13360) |
APR02845G |
Leading Biology |
0.05ml |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MUC16 / CA125 (aa13311-13360). This antibody is tested and proven to work in the following applications: |
Polyclonal MUC16 / CA125 Antibody (C-Term) |
APG00669G |
Leading Biology |
0.1mg |
EUR 484 |
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human MUC16 / CA125 (C-Term). This antibody is tested and proven to work in the following applications: |
Human MUC16 shRNA Plasmid |
20-abx964235 |
Abbexa |
|
|
|
Mouse MUC16 ELISA Kit |
STJ150303 |
St John's Laboratory |
1 kit |
EUR 412 |
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of CA125 in Mouse serum, plasma and other biological fluids |
Human MUC16 ELISA Kit |
STJ150507 |
St John's Laboratory |
1 kit |
EUR 412 |
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of CA125 in human serum, plasma and other biological fluids |
Anti-MUC16-VC-MMAE ADC |
ADC-W-564 |
Creative Biolabs |
1mg |
Ask for price |
Description: This ADC product is comprised of an anti-MUC16 monoclonal antibody conjugated via a VC linker to MMAE |
MUC16 ELISA Kit (Human) (OKBB01014) |
OKBB01014 |
Aviva Systems Biology |
96 Wells |
EUR 505 |
Description: Description of target: CA-125, also known as mucin 16 or MUC16, is a protein that in humans is encoded by the MUC16 gene. MUC16 is a member of the mucin family glycoproteins. It is a component of the ocular surface, the respiratory tract and the female reproductive tract epithelia. Since MUC16 is highly glycosylated it creates a hydrophilic environment that acts as a lubricating barrier against foreign particles and infectious agents on the apical membrane of epithelial cells. Also, the cytoplasmic tail of MUC16 has been shown to interact with cytoskeleton by binding members of the ERM protein family. The expression of mucin 16 has been shown to be altered in dry eye, cystic fibrosis, and several types of cancers.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml |
MUC16 ELISA Kit (Human) (OKCD06085) |
OKCD06085 |
Aviva Systems Biology |
96 Wells |
EUR 753 |
Description: Description of target: This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.58U/mL |
MUC16 ELISA Kit (Human) (OKAN04329) |
OKAN04329 |
Aviva Systems Biology |
96 Wells |
EUR 792 |
Description: Description of target: This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.58 U/mL |
MUC16 ELISA Kit (Rat) (OKEI00807) |
OKEI00807 |
Aviva Systems Biology |
96 Wells |
EUR 767 |
Description: Description of target: ;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 4.688U/mL |
MUC16 ELISA Kit (Mouse) (OKWB00244) |
OKWB00244 |
Aviva Systems Biology |
96 Wells |
EUR 572 |
Description: Description of target: ;Species reactivity: Mouse;Application: ;Assay info: Assay Type: Quantitative Sandwich ELISA;Sensitivity: 1.875 U/mL |
MUC16 ORF Vector (Human) (pORF) |
ORF025731 |
ABM |
1.0 ug DNA |
Ask for price |
Rabbit Anti-Human MUC16 monoclonal antibody, clone TO1826 |
CABT-L757 |
Creative Diagnostics |
100 ul |
EUR 777 |
Ovarian Cancer-Related Tumor Marker CA125 (MUC16) Antibody |
20-abx121442 |
Abbexa |
-
EUR 300.00
-
EUR 439.00
-
EUR 189.00
|
|
|
Ovarian Cancer-Related Tumor Marker CA125 (MUC16) Antibody |
20-abx135924 |
Abbexa |
-
EUR 411.00
-
EUR 592.00
-
EUR 182.00
-
EUR 314.00
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
Ovarian Cancer-Related Tumor Marker CA125 (MUC16) Antibody |
20-abx113889 |
Abbexa |
|
|
|
Ovarian Cancer-Related Tumor Marker CA125 (MUC16) Antibody |
20-abx110007 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Ovarian Cancer-Related Tumor Marker CA125 (MUC16) Antibody |
20-abx013727 |
Abbexa |
-
EUR 314.00
-
EUR 98.00
-
EUR 398.00
-
EUR 495.00
|
- 100 ug
- 10 ug
- 200 ug
- 300 µg
|
|
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNC942349-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), CF594 conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNC942349-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), CF594 conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNCA2349-250 |
Biotium |
250uL |
EUR 394 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), APC conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNC802349-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), CF680 conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNC802349-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), CF680 conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNC812349-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), CF680R conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNC812349-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), CF680R conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNCAP2349-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNCAP2349-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNC472349-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), CF647 conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNC472349-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), CF647 conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNC432349-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), CF543 conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNC432349-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), CF543 conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNC882349-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), CF488A conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNC882349-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), CF488A conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNCH2349-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNCH2349-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNCP2349-250 |
Biotium |
250uL |
EUR 394 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), PerCP conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNC042349-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), CF405S conjugate, Concentration: 0.1mg/mL |
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) Antibody |
BNC042349-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), CF405S conjugate, Concentration: 0.1mg/mL |
Ovarian Cancer-Related Tumor Marker CA125 (MUC16) Antibody |
abx430563-200ul |
Abbexa |
200 ul |
EUR 286 |
|
Ovarian Cancer-Related Tumor Marker CA125 (Muc16) Antibody |
abx432168-200ul |
Abbexa |
200 ul |
EUR 286 |
|
Ovarian Cancer-Related Tumor Marker CA125 (MUC16) Antibody |
20-abx322829 |
Abbexa |
|
|
|
Ovarian Cancer-Related Tumor Marker CA125 (MUC16) Antibody |
abx216976-100ug |
Abbexa |
100 ug |
EUR 439 |
|
Ovarian Cancer-Related Tumor Marker CA125 (MUC16) Antibody |
20-abx339194 |
Abbexa |
|
|
|
Monoclonal MUC16 / CA125 Antibody (clone X306), Clone: X306 |
AMM01778G |
Leading Biology |
0.05mg |
EUR 484 |
Description: A Monoclonal antibody against Human MUC16 / CA125 (clone X306). The antibodies are raised in Mouse and are from clone X306. This antibody is applicable in WB and IHC-P, E |
In view of the latest proliferation of mechanisms implicated within the pathogenesis, modulation and, probably, remedy of hysteria issues, that is an opportune second to survey their practical and pathophysiological significance, and to evaluate their affect upon efficiency within the VCT and different fashions of potential anxiolytic properties.