Oxidative stress is usually outlined as an imbalance of pro-oxidants and antioxidants, which could be quantified in people because the redox state of plasma GSH/GSSG. Plasma GSH redox in people turns into oxidized with age, in response to oxidative stress (chemotherapy, smoking), and in frequent illnesses (kind 2 diabetes, heart problems).
Nevertheless, information additionally present that redox of plasma GSH/GSSG just isn’t equilibrated with the bigger plasma cysteine/cystine (Cys/CySS) pool, indicating that the “stability” of pro-oxidants and antioxidants can’t be outlined by a single entity. The most important mobile thiol/disulfide programs, together with GSH/GSSG, thioredoxin- 1 (-SH(2)/-SS-), and Cys/CySS, usually are not in redox equilibrium and reply in another way to chemical toxicants and physiologic stimuli.
Particular person signaling and management occasions happen by means of discrete redox pathways quite than by means of mechanisms which are immediately conscious of a world thiol/disulfide stability similar to that conceptualized within the frequent definition of oxidative stress.
Thus, from a mechanistic standpoint, oxidative stress could also be higher outlined as a disruption of redox signaling and management. Adoption of such a definition may redirect analysis to determine key perturbations of redox signaling and management and result in new therapies for oxidative stress-related illness processes.
Complete evaluation of kinase inhibitor selectivity.
We examined the interplay of 72 kinase inhibitors with 442 kinases protecting >80% of the human catalytic protein kinome. Our information present that, as a category, kind II inhibitors are extra selective than kind I inhibitors, however that there are vital exceptions to this development. The information additional illustrate that selective inhibitors have been developed towards the vast majority of kinases focused by the compounds examined.
Evaluation of the interplay patterns reveals a category of ‘group-selective’ inhibitors broadly lively towards a single subfamily of kinases, however selective outdoors that subfamily. The information set suggests compounds to make use of as instruments to check kinases for which no devoted inhibitors exist.
It additionally supplies a basis for additional exploring kinase inhibitor biology and toxicity, in addition to for finding out the structural foundation of the noticed interplay patterns. Our findings will assist to appreciate the direct enabling potential of genomics for drug growth and fundamental analysis about mobile signaling.
Omega-Three fatty acids and heart problems: results on danger components, molecular pathways, and scientific occasions.
We reviewed obtainable proof for cardiovascular results of n-Three polyunsaturated fatty acid (PUFA) consumption, specializing in lengthy chain (seafood) n-Three PUFA, together with their principal dietary sources, results on physiological danger components, potential molecular pathways and bioactive metabolites, results on particular scientific endpoints, and present dietary pointers.
Main dietary sources embrace fatty fish and different seafood. n-Three PUFA consumption lowers plasma triglycerides, resting coronary heart fee, and blood stress and may additionally enhance myocardial filling and effectivity, decrease irritation, and enhance vascular operate.
Experimental research exhibit direct anti-arrhythmic results, which have been difficult to doc in people. n-Three PUFA have an effect on a myriad of molecular pathways, together with alteration of bodily and chemical properties of mobile membranes, direct interplay with and modulation of membrane channels and proteins, regulation of gene expression through nuclear receptors and transcription components, modifications in eicosanoid profiles, and conversion of n-Three PUFA to bioactive metabolites.
In potential observational research and adequately powered randomized scientific trials, advantages of n-Three PUFA appear most constant for coronary coronary heart illness mortality and sudden cardiac loss of life. Potential results on different cardiovascular outcomes are less-well-established, together with conflicting proof from observational research and/or randomized trials for results on nonfatal myocardial infarction, ischemic stroke, atrial fibrillation, recurrent ventricular arrhythmias, and coronary heart failure.
Analysis gaps embrace the relative significance of various physiological and molecular mechanisms, exact dose-responses of physiological and scientific results, whether or not fish oil supplies all the advantages of fish consumption, and scientific results of plant-derived n-Three PUFA.
Total, present information present sturdy concordant proof that n-Three PUFA are bioactive compounds that cut back danger of cardiac loss of life. Nationwide and worldwide pointers have converged on constant suggestions for the final inhabitants to devour no less than 250 mg/day of long-chain n-Three PUFA or no less than 2 servings/week of oily fish.
A circuitry mannequin of the expression of behavioral sensitization to amphetamine-like psychostimulants.
Repeated publicity to psychostimulants similar to cocaine and amphetamine produces behavioral sensitization, which is characterised by an augmented locomotor response to a subsequent psychostimulant problem injection. Experimentation centered on the neural underpinnings of behavioral sensitization has progressed from a singular concentrate on dopamine transmission within the nucleus accumbens and striatum to the research of mobile and molecular mechanisms that happen all through the neural circuitry wherein the mesocorticolimbic dopamine projections are embedded.
This analysis effort has yielded a conglomerate of information that has resisted easy interpretations, primarily as a result of no single neuronal impact is prone to be accountable for the expression of behavioral sensitization. The current evaluation examines the literature and critically evaluates the extent to which the neural penalties of repeated psychostimulant administration are related to the expression of behavioral sensitization.
The neural alterations discovered to contribute to the long-term expression of behavioral sensitization are centered in a set of interconnected limbic nuclei, that are termed the ‘motive’ circuit. This neural circuit is used as a template to arrange the related biochemical and molecular findings right into a mannequin of the expression of behavioral sensitization.
Oxidative stress as a significant wrongdoer in kidney illness in diabetes.
It’s postulated that localized tissue oxidative stress is a key element within the growth of diabetic nephropathy. There stays controversy, nonetheless, as as to whether that is an early hyperlink between hyperglycemia and renal illness or develops as a consequence of different major pathogenic mechanisms.
Within the kidney, a variety of pathways that generate reactive oxygen species (ROS) similar to glycolysis, particular defects within the polyol pathway, uncoupling of nitric oxide synthase, xanthine oxidase, NAD(P)H oxidase, and superior glycation have been recognized as doubtlessly main contributors to the pathogenesis of diabetic kidney illness.
As well as, a unifying speculation has been proposed whereby mitochondrial manufacturing of ROS in response to persistent hyperglycemia often is the key initiator for every of those pathogenic pathways. This postulate emphasizes the significance of mitochondrial dysfunction within the development and growth of diabetes issues together with nephropathy.
A thriller stays, nonetheless, as to why antioxidants per se have demonstrated minimal renoprotection in people regardless of constructive preclinical analysis findings. It’s doubtless that the utility of present research approaches, similar to vitamin use, will not be the perfect antioxidant technique in human diabetic nephropathy.
CFDA SE Cell Tracer Kit |
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K1023-1 | ApexBio | 1 kit | EUR 96 |
Description: The CFDA SE (carboxyfluorescein diacetate succinimidyl ester) Cell Tracer Kit is usually used in fluorescence analyses as a long-term tracer of cells. The Kit can be used for in vitro and in vivo labeling of cells to determine whether or not a cell is proliferating, especially. |
FluoGreen Tracer, Stains Cell Nuclei and Cytoplasm |
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MBS555420-01mL | MyBiosource | 0.1mL | EUR 435 |
FluoGreen Tracer, Stains Cell Nuclei and Cytoplasm |
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MBS555420-5x01mL | MyBiosource | 5x0.1mL | EUR 1815 |
CFDA SE cell proliferation and tracer detection kit |
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ETF0051 | EnoGene | 2000 assays | EUR 300 |
CFDA SE cell prolifeRation and tracer detection kit |
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MBS8579509-2000Assays | MyBiosource | 2000Assays | EUR 400 |
CFDA SE cell prolifeRation and tracer detection kit |
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MBS8579509-5x2000Assays | MyBiosource | 5x2000Assays | EUR 1810 |
FluoGreen Tracer |
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SF41000 | Neuromics | 100 ul | EUR 522 |
Tau tracer 1 |
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T39660-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Tau tracer 1 |
Tau tracer 1 |
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T39660-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Tau tracer 1 |
Tau tracer 1 |
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T39660-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Tau tracer 1 |
Tau tracer 1 |
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T39660-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Tau tracer 1 |
Tau tracer 1 |
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T39660-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Tau tracer 1 |
Tau tracer 2 |
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T37051-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Tau tracer 2 |
Tau tracer 2 |
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T37051-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Tau tracer 2 |
Tau tracer 2 |
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T37051-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Tau tracer 2 |
Tau tracer 2 |
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T37051-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Tau tracer 2 |
Tau tracer 2 |
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T37051-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Tau tracer 2 |
Tau tracer 2 |
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MBS5798041-50mg | MyBiosource | 50(mg | EUR 960 |
Tau tracer 2 |
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MBS5798041-5x50mg | MyBiosource | 5x50(mg | EUR 4180 |
Tau tracer 1 |
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MBS5800094-5mg | MyBiosource | 5(mg | EUR 915 |
Tau tracer 1 |
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MBS5800094-5x5mg | MyBiosource | 5x5(mg | EUR 3970 |
Tau tracer 1 |
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HY-134879 | MedChemExpress | Get quote | Ask for price |
Description: Tau tracer 1 is a Tau tracer used for imaging Tau protein aggregates. Tau tracer 1 can be used to diagnose neurodegenerative diseases[1]. |
Tau tracer 2 |
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HY-134880 | MedChemExpress | 10 mg | EUR 216.45 |
Description: Tau tracer 2 (Pl-2620) is a Tau tracer used for imaging Tau protein aggregates. Tau tracer 2 can be used to diagnose neurodegenerative diseases[1]. |
JAK2 JH2 Tracer |
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HY-102055 | MedChemExpress | 50mg | EUR 5515.2 |
JAK2 JH2 Tracer |
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T19017-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: JAK2 JH2 Tracer |
JAK2 JH2 Tracer |
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T19017-1g | TargetMol Chemicals | 1g | Ask for price |
Description: JAK2 JH2 Tracer |
JAK2 JH2 Tracer |
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T19017-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: JAK2 JH2 Tracer |
JAK2 JH2 Tracer |
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T19017-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: JAK2 JH2 Tracer |
JAK2 JH2 Tracer |
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T19017-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: JAK2 JH2 Tracer |
JAK2 JH2 Tracer |
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MBS3844504-10mg | MyBiosource | 10mg | EUR 855 |
JAK2 JH2 Tracer |
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MBS3844504-1mg | MyBiosource | 1mg | EUR 225 |
JAK2 JH2 Tracer |
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MBS3844504-50mg | MyBiosource | 50mg | EUR 2450 |
JAK2 JH2 Tracer |
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MBS3844504-5mg | MyBiosource | 5mg | EUR 525 |
JAK2 JH2 Tracer |
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MBS3844504-5x50mg | MyBiosource | 5x50mg | EUR 11020 |
JAK2 JH2 Tracer |
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MBS5755856-50mg | MyBiosource | 50mg | EUR 2840 |
JAK2 JH2 Tracer |
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MBS5755856-5x50mg | MyBiosource | 5x50mg | EUR 12620 |
ROS tracer precursor |
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T19550-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: ROS tracer precursor |
ROS tracer precursor |
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T19550-1g | TargetMol Chemicals | 1g | Ask for price |
Description: ROS tracer precursor |
ROS tracer precursor |
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T19550-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: ROS tracer precursor |
ROS tracer precursor |
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T19550-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: ROS tracer precursor |
ROS tracer precursor |
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T19550-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: ROS tracer precursor |
ROS tracer precursor |
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MBS5772039-5mg | MyBiosource | 5mg | EUR 915 |
ROS tracer precursor |
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MBS5772039-5x5mg | MyBiosource | 5x5mg | EUR 3970 |
ROS tracer precursor |
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HY-126712 | MedChemExpress | Get quote | Ask for price |
Description: ROS tracer precursor is the precursor of [18F]ROStrace for the synthesis of ROStrace, which can be used for disease diagnosis[1]. |
CytoFixâ„¢ BCECF, AM *Optimized for long term cellular pH tracking* |
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21200-1mg | AAT Bioquest | 1 mg | EUR 318 |
Description: Intracellular pH plays an important modulating role in many cellular events, including cell growth, calcium regulation, enzymatic activity, receptor-mediated signal transduction, ion transport, endocytosis, chemotaxis, cell adhesion and other cellular processes. |
Long-Term Cell Tracing Reagent CMAC (Blue) |
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EGY0171 | EnoGene | 100µg | EUR 92 |
Long-Term Cell Tracing Reagent CMAC (Blue) |
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EGY0172 | EnoGene | 5x100µg | EUR 340 |
Long-Term Cell Tracing Reagent CMAC (Blue) |
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MBS8579546-01mg | MyBiosource | 0.1mg | EUR 185 |
Long-Term Cell Tracing Reagent CMAC (Blue) |
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MBS8579546-5x01mg | MyBiosource | 5x0.1mg | EUR 420 |
Long-Term Cell Tracing Reagent CMFDA(Green) |
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EGY0181 | EnoGene | 100µg | EUR 220 |
Long-Term Cell Tracing Reagent CMFDA(Green) |
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EGY0182 | EnoGene | 5x100µg | EUR 500 |
Long-Term Cell Tracing Reagent CMFDA (Green) |
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MBS8579547-01mg | MyBiosource | 0.1mg | EUR 300 |
Long-Term Cell Tracing Reagent CMFDA (Green) |
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MBS8579547-5x01mg | MyBiosource | 5x0.1mg | EUR 580 |
Long-Term Cell Tracing Reagent CDCFDA, SE (Green) |
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EGY0161 | EnoGene | 100 µg | EUR 160 |
Long-Term Cell Tracing Reagent CDCFDA, SE (Green) |
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EGY0162 | EnoGene | 5 x 100 µg | EUR 340 |
Long-Term Cell Tracing Reagent CDCFDA, SE (Green) |
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MBS8579545-01mg | MyBiosource | 0.1mg | EUR 245 |
Long-Term Cell Tracing Reagent CDCFDA, SE (Green) |
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MBS8579545-5x01mg | MyBiosource | 5x0.1mg | EUR 420 |
IAA tracer (alkaline phospahatase conjugated) |
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AS09-517 | Agrisera AB | 1000 assays | EUR 208 |
ABA tracer (alkaline phospahatase conjugated) |
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AS10-726 | Agrisera AB | 1000 assays | EUR 230 |
NIR-FLIVO 690 Tracer In vivo Assay |
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MBS258410-20Tests | MyBiosource | 20Tests | EUR 535 |
NIR-FLIVO 690 Tracer In vivo Assay |
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MBS258410-5x20Tests | MyBiosource | 5x20Tests | EUR 2460 |
NIR-FLIVO 747 Tracer In vivo Assay |
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MBS258412-20Tests | MyBiosource | 20Tests | EUR 535 |
NIR-FLIVO 747 Tracer In vivo Assay |
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MBS258412-5x20Tests | MyBiosource | 5x20Tests | EUR 2460 |
CytoSelect™ Cell Transformation Assay (Cell Recovery Compatible), Colorimetric |
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CBA-135 | Cell Biolabs | 96 assays | EUR 715 |
CytoSelect™ Cell Transformation Assay (Cell Recovery Compatible), Colorimetric |
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CBA-135-5 | Cell Biolabs | 5 x 96 assays | EUR 3095 |
CytoSelect™ Cell Transformation Assay (Cell Recovery Compatible), Fluorometric |
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CBA-140 | Cell Biolabs | 96 assays | EUR 750 |
CytoSelect™ Cell Transformation Assay (Cell Recovery Compatible), Fluorometric |
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CBA-140-5 | Cell Biolabs | 5 x 96 assays | EUR 3215 |
Cis-zeatin tracer (alkaline phospahatase conjugated) |
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AS16-4092 | Agrisera AB | 1000 assays | EUR 230 |
Trans-zeatin tracer (alkaline phospahatase conjugated) |
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AS16-4090 | Agrisera AB | 1000 assays | EUR 230 |
NIR-FLIVO® 690 Tracer In vivo Assay |
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9112 | Immunochemistry | 20 Tests | EUR 438 |
NIR-FLIVO® 747 Tracer In vivo Assay |
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9114 | Immunochemistry | 20 Tests | EUR 438 |
CytoSelect Cell Transformation Assay (Cell Recovery Compatible), Colorimetric, Trial Size |
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CBA-135-T | Cell Biolabs | 24 assays | EUR 518.4 |
Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis. |
CytoSelect 96-Well Cell Transformation Assay (Cell Recovery Compatible, Fluorometric), Trial Size |
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CBA-140-T | Cell Biolabs | 24 assays | EUR 547.2 |
Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis. |
N6-isopentenyladenosine tracer (alkaline phospahatase conjugated) |
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AS17-4132 | Agrisera AB | 1000 assays | EUR 208 |
CytoSelect™ 96-well Cell Transformation Assay |
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CBA-130 | Cell Biolabs | 96 assays | EUR 640 |
CytoSelect™ 96-well Cell Transformation Assay |
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CBA-130-5 | Cell Biolabs | 5 x 96 assays | EUR 2695 |
HRP conjugated mAb anti-Human TNF-alpha (Tracer) |
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MBS592166-02mL | MyBiosource | 0.2mL | EUR 580 |
HRP conjugated mAb anti-Human TNF-alpha (Tracer) |
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MBS592166-5x02mL | MyBiosource | 5x0.2mL | EUR 2355 |
Biotin conjugated mAb anti-Human TNF-alpha (Tracer) |
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MBS592389-01mL | MyBiosource | 0.1mL | EUR 580 |
Biotin conjugated mAb anti-Human TNF-alpha (Tracer) |
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MBS592389-5x01mL | MyBiosource | 5x0.1mL | EUR 2355 |
CytoSelect 384-well Cell Transformation Assay, Fluorometric |
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CBA-145 | Cell Biolabs | 384 assays | EUR 1208.4 |
Description: Our CytoSelect 384-Well Cell Transformation Assay uses a modified soft agar 3D matrix to support the formation of colonies by neoplastic cells. Quantitation of cell transformation is performed on a fluorescence plate reader. |
CytoSelect 384-well Cell Transformation Assay, Fluorometric |
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CBA-145-5 | Cell Biolabs | 5 x 384 assays | EUR 4681.2 |
Description: Our CytoSelect 384-Well Cell Transformation Assay uses a modified soft agar 3D matrix to support the formation of colonies by neoplastic cells. Quantitation of cell transformation is performed on a fluorescence plate reader. |
293AD Cell Line |
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AD-100 | Cell Biolabs | 1 vial | EUR 365 |
293AAV Cell Line |
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AAV-100 | Cell Biolabs | 1 vial | EUR 405 |
293LTV Cell Line |
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LTV-100 | Cell Biolabs | 1 vial | EUR 405 |
293RTV Cell Line |
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RV-100 | Cell Biolabs | 1 vial | EUR 405 |
StemTAG Stem Cell Colony Formation Assay (Cell Recovery Compatible) |
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CBA-325 | Cell Biolabs | 96 assays | EUR 1027.2 |
Description: Our StemTAG 96-Well Stem Cell Colony Formation Assay provides a high-throughput method to quantify ES cells in just 7-10 days, and no manual cell counting is required. Once colonies are formed, they may be analyzed in three different ways: 1. Lyse cells, then quantify in a fluorescence plate reader using dye included in the kit; 2. Lyse cells, then quantify alkaline phosphatase activity using reagents provided; or 3. Recover colonies from matrix for further culture or analysis. |
StemTAG Stem Cell Colony Formation Assay (Cell Recovery Compatible) |
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CBA-325-5 | Cell Biolabs | 5 x 96 assays | EUR 4033.2 |
Description: Our StemTAG 96-Well Stem Cell Colony Formation Assay provides a high-throughput method to quantify ES cells in just 7-10 days, and no manual cell counting is required. Once colonies are formed, they may be analyzed in three different ways: 1. Lyse cells, then quantify in a fluorescence plate reader using dye included in the kit; 2. Lyse cells, then quantify alkaline phosphatase activity using reagents provided; or 3. Recover colonies from matrix for further culture or analysis. |
293/GFP Cell Line |
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AKR-200 | Cell Biolabs | 1 vial | EUR 460 |
T47D/GFP Cell Line |
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AKR-208 | Cell Biolabs | 1 vial | EUR 686.4 |
Description: T47D/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line. |
A549/GFP Cell Line |
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AKR-209 | Cell Biolabs | 1 vial | EUR 460 |
HeLa/GFP Cell Line |
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AKR-213 | Cell Biolabs | 1 vial | EUR 460 |
293/Cas9 Cell Line |
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AKR-5110 | Cell Biolabs | 1 vial | EUR 460 |
HeLa/Cas9 Cell Line |
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AKR-5111 | Cell Biolabs | 1 vial | EUR 460 |
NIH3T3/GFP Cell Line |
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AKR-214 | Cell Biolabs | 1 vial | EUR 460 |
NIH3T3/Cas9 Cell Line |
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AKR-5104 | Cell Biolabs | 1 vial | EUR 460 |
MCF-7/Luc Cell Line |
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AKR-234 | Cell Biolabs | 1 vial | EUR 686.4 |
Description: MCF-7/Luc Cell Line stably expresses luciferase and otherwise exhibits the same characteristics of the parental cell line. |
SKOV-3/Luc Cell Line |
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AKR-232 | Cell Biolabs | 1 vial | EUR 686.4 |
Description: SKOV-3/Luc Cell Line stably expresses luciferase and otherwise exhibits the same characteristics of the parental cell line. |
OVCAR-5/RFP Cell Line |
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AKR-254 | Cell Biolabs | 1 vial | EUR 686.4 |
Description: OVCAR-5/RFP Cell Line stably expresses RFP and otherwise exhibits the same characteristics of the parental cell line. |
mAb Anti Human PD-L1 clone 12B4, Tracer (Biotin) (Monoclonal) |
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MBS590085-01mL | MyBiosource | 0.1mL | EUR 565 |
mAb Anti Human PD-L1 clone 12B4, Tracer (Biotin) (Monoclonal) |
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MBS590085-5x01mL | MyBiosource | 5x0.1mL | EUR 2290 |
mAb Anti-Human PD-1/CD279, 7G12, Tracer (Biotin) (Monoclonal |
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MBS590084-01mL | MyBiosource | 0.1mL | EUR 565 |
mAb Anti-Human PD-1/CD279, 7G12, Tracer (Biotin) (Monoclonal |
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MBS590084-5x01mL | MyBiosource | 5x0.1mL | EUR 2290 |
CytoSelect™ 96-Well Cell Transformation Assay (Soft Agar Colony Formation), Trial Size |
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CBA-130-T | Cell Biolabs | 24 assays | EUR 320 |
Collagen-based Cell Contraction Assay |
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CBA-201 | Cell Biolabs | 24 assays | EUR 420 |
Radius 384-Well Cell Migration Assay |
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CBA-127 | Cell Biolabs | 384 assays | EUR 721.2 |
Description: The Radius Cell Migration Assay provides a unique alternative to conventional cell migration assays using the Boyden chamber. Unlike Boyden chamber assays which may only be analyzed at endpoint, the Radius assay uses a proprietary cell culture plate containing a carefully-defined biocompatible hydrogel (Radius gel) spot centralized at the bottom of each well. When cells are seeded in the well, they will attach everywhere except on the Radius gel, creating a cell-free zone. Following cell seeding the Radius gel is removed, allowing migratory cells to move across the area and close the gap. |
Radius 384-Well Cell Migration Assay |
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CBA-127-5 | Cell Biolabs | 5 x 384 wells | EUR 2802 |
Description: The Radius Cell Migration Assay provides a unique alternative to conventional cell migration assays using the Boyden chamber. Unlike Boyden chamber assays which may only be analyzed at endpoint, the Radius assay uses a proprietary cell culture plate containing a carefully-defined biocompatible hydrogel (Radius gel) spot centralized at the bottom of each well. When cells are seeded in the well, they will attach everywhere except on the Radius gel, creating a cell-free zone. Following cell seeding the Radius gel is removed, allowing migratory cells to move across the area and close the gap. |
HIF-1 Alpha Cell Based ELISA Kit |
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CBA-281 | Cell Biolabs | 96 assays | EUR 734.4 |
Description: Cell Biolabs? HIF-1 Cell Based ELISA Kit is an immunoassay developed for rapid detection of HIF-1 Alpha in fixed cells. Cells on a microplate are stimulated for HIF-1 Alpha stabilization, fixed, permeabilized, and then neutralized in the well. HIF-1 Alpha is then detected with an anti-HIF-1 alpha antibody followed by an HRP conjugated secondary antibody. Each kit provides sufficient reagents to perform up to a total of 96 assays and can detect HIF-1 Alpha from human, mouse, or rat. |
CytoSelect™ MTT Cell Proliferation Assay |
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CBA-252 | Cell Biolabs | 960 assays | EUR 320 |
Radius™ 24-Well Cell Migration Assay |
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CBA-125 | Cell Biolabs | 24 assays | EUR 425 |
Radius™ 24-Well Cell Migration Assay |
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CBA-125-5 | Cell Biolabs | 5 x 24 assays | EUR 1820 |
Radius™ 96-Well Cell Migration Assay |
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CBA-126 | Cell Biolabs | 96 assays | EUR 495 |
Radius™ 96-Well Cell Migration Assay |
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CBA-126-5 | Cell Biolabs | 5 x 96 assays | EUR 2095 |
Radius™ 48-Well Cell Migration Assay |
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CBA-5037 | Cell Biolabs | 48 assays | EUR 445 |
Radius™ 48-Well Cell Migration Assay |
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CBA-5037-5 | Cell Biolabs | 5 x 48 assays | EUR 1895 |
CytoSelect Cell Proliferation Assay Reagent (Fluorometric) |
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CBA-250 | Cell Biolabs | 10 mL | EUR 490.8 |
Description: Cell Biolabs? CytoSelect Cell Proliferation Assay Reagent (Fluorometric) provides a fluorometric format for measuring and monitoring cell proliferation. Cells can be plated and then treated with compounds or agents that affect proliferation. Cells are then incubated with the proliferation reagent. Upon entering metabolically active live cells, the non-fluorescent proliferation reagent is converted into a bright red fluorescent form. An increase in cell proliferation is accompanied by increased fluorescent signal, while a decrease in cell proliferation (and signal) can indicate the toxic effects of compounds or suboptimal culture conditions. The assay principles are basic and can be applied to most eukaryotic cell lines, including adherent and non-adherent cells and certain tissues. This cell proliferation reagent can be used to detect proliferation in bacteria, yeast, fungi, protozoa as well as cultured mammalian and piscine cells. The kit contains sufficient reagents for the evaluation of 960 assays in ten 96-well plates or 192 assays in eight 24-well plates. |
CytoSelect™ BrdU Cell Proliferation ELISA Kit |
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CBA-251 | Cell Biolabs | 96 assays | EUR 455 |
CytoSelect™ Cell Viability and Cytotoxicity Assay |
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CBA-240 | Cell Biolabs | 96 assays | EUR 305 |
Platinum-E Retroviral Packaging Cell Line, Ecotropic |
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RV-101 | Cell Biolabs | 1 vial | EUR 770 |
Platinum-GP Retroviral Packaging Cell Line, Pantropic |
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RV-103 | Cell Biolabs | 1 vial | EUR 770 |
CytoSelect 24-well Laminin Cell Invasion, Colorimetric |
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CBA-110-LN | Cell Biolabs | 12 assays | EUR 714 |
Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 24-well plates on either a standard microplate reader or a fluorescence plate reader. Inserts are precoated on the top of the membrane with Laminin. |
Platinum-A Retroviral Packaging Cell Line, Amphotropic |
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RV-102 | Cell Biolabs | 1 vial | EUR 770 |
CytoSelect™ 24-Well Cell Co-Culture System |
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CBA-160 | Cell Biolabs | 24 assays | EUR 365 |
CytoSelect™ 24-Well Cell Co-Culture System |
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CBA-160-5 | Cell Biolabs | 5 x 24 assays | EUR 1585 |
Total Protein - Murine Embryonic Stem Cell Line D3 |
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CBA-305 | Cell Biolabs | 500 ?g | EUR 414 |
Description:
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CytoSelect™ 48-Well Cell Contraction Assay Kit |
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CBA-5021 | Cell Biolabs | 48 assays | EUR 575 |
CytoSelect™ Cell Proliferation Assay Reagent (Colorimetric) |
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CBA-253 | Cell Biolabs | 10 mL | EUR 320 |
Radius 24-Well Cell Migration Assay, (Laminin Coated) |
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CBA-125-LN | Cell Biolabs | 24 assays | EUR 714 |
Description: The Radius Cell Migration Assay provides a unique alternative to conventional cell migration assays using the Boyden chamber. Unlike Boyden chamber assays which may only be analyzed at endpoint, the Radius assay uses a proprietary cell culture plate containing a carefully-defined biocompatible hydrogel (Radius gel) spot centralized at the bottom of each well. When cells are seeded in the well, they will attach everywhere except on the Radius gel, creating a cell-free zone. Following cell seeding the Radius gel is removed, allowing migratory cells to move across the area and close the gap. |
StemTAG PCR Primer Set for Stem Cell Characterization |
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CBA-303 | Cell Biolabs | 1 kit | EUR 470.4 |
Description: StemTAG PCR Primer Set for Stem Cell Characterization includes 7 primer pairs: Oct-4, NANOG, AFP, Flk-1, and NCAM, plus GAPDH and beta-actin as controls. |
CytoSelect Clonogenic Tumor Cell Isolation Kit (5 preps) |
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CBA-155 | Cell Biolabs | 5 preps | EUR 957.6 |
Description: Many solid tumors contain heterogeneous populations of normal and cancerous cells. Separation of these cell populations is key to an accurate assessment of the true genotypic and phenotypic differences between normal and tumor cells. Our CytoSelect Clonogenic Tumor Cell Isolation Kit uses a proprietary semisolid agar medium to facilitate formation of colonies by cells from solid tumors. Colonies are grown in either a 6-well plate or a 35mm culture dish. These colonies are isolated away from single (i.e. normal) cells by size filtration. The viable cells from these colonies can be easily recovered for further analysis. |
Radius 24-Well Cell Migration Assay, (Fibronectin Coated) |
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CBA-125-FN | Cell Biolabs | 24 assays | EUR 714 |
Description: The Radius Cell Migration Assay provides a unique alternative to conventional cell migration assays using the Boyden chamber. Unlike Boyden chamber assays which may only be analyzed at endpoint, the Radius assay uses a proprietary cell culture plate containing a carefully-defined biocompatible hydrogel (Radius gel) spot centralized at the bottom of each well. When cells are seeded in the well, they will attach everywhere except on the Radius gel, creating a cell-free zone. Following cell seeding the Radius gel is removed, allowing migratory cells to move across the area and close the gap. |
CytoSelect™ 24-well Collagen Cell Invasion, Colorimetric |
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CBA-110-COL | Cell Biolabs | 12 assays | EUR 535 |
CytoSelect Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit |
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CBA-254 | Cell Biolabs | 96 assays | EUR 672 |
Description: Cell Biolabs? CytoSelect Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit is an enzyme immunoassay developed for the detection and quantitation of PCNA from nuclear and whole cell extracts. The kit detects PCNA from mouse, rat and human, and has a detection sensitivity limit of 12.5 ng/mLPCNA. Each kit provides sufficient reagents to perform up to 96 assays including standard curve and unknown samples. |
Radius 24-Well Cell Migration Assay, (ECM Array Coated) |
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CBA-125-ECM | Cell Biolabs | 24 wells | EUR 838.8 |
Description: The Radius Cell Migration Assay provides a unique alternative to conventional cell migration assays using the Boyden chamber. Unlike Boyden chamber assays which may only be analyzed at endpoint, the Radius assay uses a proprietary cell culture plate containing a carefully-defined biocompatible hydrogel (Radius gel) spot centralized at the bottom of each well. When cells are seeded in the well, they will attach everywhere except on the Radius gel, creating a cell-free zone. Following cell seeding the Radius gel is removed, allowing migratory cells to move across the area and close the gap. |
CytoSelect 48-well Cell Adhesion Assay (Laminin, Colorimetric) |
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CBA-056 | Cell Biolabs | 48 assays | EUR 512.4 |
Description: Cell adhesion is a complex process involved in migration/invasion, embryogenesis, wound healing and tissue remodeling. Cells adhere to the extracellular matrix, forming complexes with cytoskeleton components that can affect cell motility, differentiation, proliferation, and survival. Our CytoSelect 48-Well Cell Adhesion Assays provide a fully quantitative method for the evaluation of cell adhesion. The 48-well plate is precoated with Laminin. |
CytoSelect 48-well Cell Adhesion Assay (Laminin, Fluorometric) |
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CBA-057 | Cell Biolabs | 48 assays | EUR 553.2 |
Description: Cell adhesion is a complex process involved in migration/invasion, embryogenesis, wound healing and tissue remodeling. Cells adhere to the extracellular matrix, forming complexes with cytoskeleton components that can affect cell motility, differentiation, proliferation, and survival. Our CytoSelect 48-Well Cell Adhesion Assays provide a fully quantitative method for the evaluation of cell adhesion. The 48-well plate is precoated with Laminin. |
CytoSelect 24-well Laminin Cell Invasion Assay, Fluorometric |
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CBA-111-LN | Cell Biolabs | 12 assays | EUR 714 |
Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 24-well plates on either a standard microplate reader or a fluorescence plate reader. Inserts are precoated on the top of the membrane with Laminin. |
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