Folate status: effects on pathways of colorectal carcinogenesis.

Folate status: effects on pathways of colorectal carcinogenesis.

Many epidemiologic, animal and human research counsel that folate standing modulates carcinogenesis. Though these observations have been made in a lot of tissues, the knowledge are clearly most compelling for the colorectum. The mechanism(s) by which this modulation is mediated stays unwell … Read More

Glutathione-associated enzymes in anticancer drug resistance.

Glutathione-associated enzymes in anticancer drug resistance.

The importance of thiol-mediated detoxification of anticancer drugs that produce toxic electrophiles has been of considerable interest to many investigators. Glutathione and glutathione S-transferases (GST) are the focus of much attention in characterizing drug resistant cells. However, ambiguous and sometimes … Read More

The role of the hippocampus in the pathophysiology of major depression.

The role of the hippocampus in the pathophysiology of major depression.

Converging lines of research suggest that the hippocampal complex (HC) may have a role in the pathophysiology of major depressive disorder (MDD). Although postmortem studies show little cellular death in the HC of depressed patients, animal studies suggest that elevated glucocorticoid levels associated with … Read More

A Wnt survival guide: from flies to human disease.

A Wnt survival guide: from flies to human disease.

It has been 20 years since investigators discovered the hyperlink between the Drosophila wingless (Wg) gene and the vertebrate oncogene int-1, thus establishing the family of signaling proteins known as Wnts. Given that inception of the Wnt signaling space, there … Read More

Charting histone modifications and the functional organization of mammalian genomes.

Charting histone modifications and the functional organization of mammalian genomes.

A succession of technological advances over the previous decade have enabled analysisers to chart maps of histone modifications and associated chromatin constructions with growing accuracy, comprehensiveness and throughput. The ensuing information units spotlight the interaction between chromatin and genome perform, dynamic variations in … Read More

The RSK family of kinases: emerging roles in cellular signalling.

The RSK family of kinases: emerging roles in cellular signalling.

The 90 kDa ribosomal S6 kinase (RSK) household of proteins is a gaggle of extremely conserved Ser/Thr kinases that regulate various mobile processes, resembling cell progress, cell motility, cell survival and cell proliferation. RSKs are downstream effectors of the Ras-extramobile signal-regulated kinase (ERK)/mitogen-activated … Read More

The consensus coding sequences of human breast and colorectal cancers.

The consensus coding sequences of human breast and colorectal cancers.

The elucidation of the human genome sequence has made it potential to ascertain genetic alterations in cancers in unprecedented component. To start out a scientific analysis of such alterations, we determined the sequence of well-annotated human protein-coding genes in two … Read More