Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy

Proliferative diabetic retinopathy (PDR) is a extreme complication of diabetes and might trigger blindness. Nevertheless, the out there therapeutic modalities to PDR have unsatisfactory efficacies and incur opposed results, which is as a result of paucity within the understanding of … Read More

Glutathione-associated enzymes in anticancer drug resistance.

Glutathione-associated enzymes in anticancer drug resistance.

The importance of thiol-mediated detoxification of anticancer drugs that produce toxic electrophiles has been of considerable interest to many investigators. Glutathione and glutathione S-transferases (GST) are the focus of much attention in characterizing drug resistant cells. However, ambiguous and sometimes … Read More