Breakthroughs in molecular profiling applied sciences are enabling a brand new data-intensive strategy to biomedical analysis, with the potential to revolutionize how we examine, handle, and deal with advanced ailments. The following nice problem for scientific functions of those improvements will probably be to create scalable computational options for intelligently linking advanced biomedical affected person knowledge to clinically actionable data.
Conventional database administration techniques (DBMS) are usually not effectively suited to representing advanced syntactic and semantic relationships in unstructured biomedical info, introducing boundaries to realizing such options. We suggest a scalable computational framework for addressing this want, which leverages a hypergraph-based knowledge mannequin and question language which may be higher fitted to representing advanced multi-lateral, multi-scalar, and multi-dimensional relationships. We additionally focus on how this framework can be utilized to create fast studying data base techniques to intelligently seize and relate advanced affected person knowledge to biomedical data with a purpose to automate the restoration of clinically actionable info.
A software program framework for constructing biomedical machine studying classifiers by means of grid computing assets.
This paper describes the BiomedTK software program framework, created to carry out large explorations of machine studying classifiers configurations for biomedical knowledge evaluation over distributed Grid computing assets. BiomedTK integrates ROC evaluation all through the whole classifier development course of and allows explorations of huge parameter sweeps for coaching third celebration classifiers resembling synthetic neural networks and assist vector machines, providing the potential to harness the huge quantity of computing energy serviced by Grid infrastructures.
As well as, it consists of classifiers modified by the authors for ROC optimization and performance to construct ensemble classifiers and manipulate datasets (import/export, extract and rework knowledge, and so forth.). BiomedTK was experimentally validated by coaching 1000’s of classifier configurations for consultant biomedical UCI datasets reaching in little time classification ranges similar to these reported in present literature. The great methodology herewith offered represents an enchancment to biomedical knowledge evaluation in each methodology and potential attain of machine studying based mostly experimentation.
Biomedical cloud computing with Amazon Internet Providers.
On this overview to biomedical computing within the cloud, we mentioned two major methods to make use of the cloud (a single occasion or cluster), supplied an in depth instance utilizing NGS mapping, and highlighted the related prices. Whereas many customers new to the cloud could assume that entry is as simple as importing an software and choosing an occasion sort and storage choices, we illustrated that there’s substantial up-front effort required earlier than an software could make full use of the cloud’s huge assets.
Our intention was to supply a set of greatest practices and as an instance how these apply to a typical software pipeline for biomedical informatics, but additionally common sufficient for extrapolation to different varieties of computational issues. Our mapping instance was supposed as an instance the way to develop a scalable undertaking and to not examine and distinction alignment algorithms for learn mapping and genome meeting.
Certainly, with a more recent aligner resembling Bowtie, it’s potential to map all the African genome utilizing one m2.2xlarge occasion in 48 hours for a complete value of roughly $48 in computation time. In our instance, we weren’t involved with knowledge switch charges, that are closely influenced by the quantity of obtainable bandwidth, connection latency, and community availability.
When transferring massive quantities of knowledge to the cloud, bandwidth limitations is usually a main bottleneck, and in some instances it’s extra environment friendly to easily mail a storage machine containing the info to AWS. Extra details about cloud computing, detailed value evaluation, and safety may be present in references.
Normalized affect issue (NIF): an adjusted methodology for calculating the quotation charge of biomedical journals.
The pursuits in journal affect issue (JIF) in scientific communities have grown over the past a long time. The JIFs are used to judge journals high quality and the papers revealed therein. JIF is a self-discipline particular measure and the comparability between the JIF devoted to totally different disciplines is insufficient, except a normalization course of is carried out.
On this examine, normalized affect issue (NIF) was launched as a comparatively easy methodology enabling the JIFs for use when evaluating the standard of journals and analysis works in several disciplines. The NIF index was established based mostly on the multiplication of JIF by a relentless issue. The constants have been calculated for all 54 disciplines of biomedical discipline throughout 2005, 2006, 2007, 2008 and 2009 years.
Additionally, rating of 393 journals in several biomedical disciplines in accordance with the NIF and JIF have been in comparison with illustrate how the NIF index can be utilized for the analysis of publications in several disciplines. The findings show that the usage of the NIF enhances the equality in assessing the standard of analysis works produced by researchers who work in several disciplines.
DOORS to the semantic net and grid with a PORTAL for biomedical computing.
The semantic net stays within the early levels of growth. It has not but achieved the targets envisioned by its founders as a pervasive net of distributed data and intelligence. Success will probably be attained when a dynamic synergism may be created between folks and a ample variety of infrastructure techniques and instruments for the semantic net in analogy with these for the unique net.
The area title system (DNS), net browsers, and the advantages of publishing net pages motivated many individuals to register domains and publish internet sites on the unique net. An identical useful resource label system, semantic search functions, and the advantages of collaborative semantic networks will encourage folks to register useful resource labels and publish useful resource descriptions on the semantic net.
The Area Ontology Oriented Useful resource System (DOORS) and Downside Oriented Registry of Tags and Labels (PORTAL) are proposed as infrastructure techniques for useful resource metadata inside a paradigm that may function a bridge between the unique net and the semantic net. The Web Registry Data Service (IRIS) registers [corrected] domains whereas DNS publishes area addresses with mapping of names to addresses for the unique net.
Cyclin D1 Antibody |
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| ABD6386 | Lifescience Market | 100 ug | EUR 438 |
Cyclin D1 Antibody |
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| ABF0931 | Lifescience Market | 100 ug | EUR 438 |
Cyclin D1 Antibody |
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| DF6386 | Affbiotech | 200ul | EUR 304 |
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Description: Cyclin D1 Antibody detects endogenous levels of total Cyclin D1. |
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Cyclin D1 Antibody |
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| ABF6234 | Lifescience Market | 100 ug | EUR 438 |
Cyclin D1 Antibody |
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| AF0931 | Affbiotech | 200ul | EUR 304 |
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Description: Cyclin D1 Antibody detects endogenous levels of total Cyclin D1. |
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Cyclin D1 antibody |
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| 10R-10331 | Fitzgerald | 100 ug | EUR 435 |
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Description: Mouse monoclonal Cyclin D1 antibody |
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Cyclin D1 antibody |
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| 10R-7849 | Fitzgerald | 100 ug | EUR 305 |
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Description: Mouse monoclonal Cyclin D1 antibody |
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Cyclin D1 antibody |
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| 10R-8605 | Fitzgerald | 100 ul | EUR 393 |
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Description: Mouse monoclonal Cyclin D1 antibody |
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Cyclin D1 antibody |
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| 10R-C148a | Fitzgerald | 100 ug | EUR 457 |
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Description: Mouse monoclonal Cyclin D1 antibody |
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Cyclin D1 antibody |
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| 10R-2363 | Fitzgerald | 50 ug | EUR 313 |
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Description: Mouse monoclonal Cyclin D1 antibody |
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Cyclin D1 antibody |
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| 10R-2414 | Fitzgerald | 5 mL | EUR 194 |
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Description: Mouse monoclonal Cyclin D1 antibody |
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Cyclin D1 antibody |
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| 70R-30875 | Fitzgerald | 100 ug | EUR 327 |
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Description: Rabbit polyclonal Cyclin D1 antibody |
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Cyclin D1 antibody |
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| 70R-33524 | Fitzgerald | 100 ug | EUR 327 |
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Description: Rabbit polyclonal Cyclin D1 antibody |
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Cyclin D1 antibody |
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| 70R-13838 | Fitzgerald | 100 ug | EUR 305 |
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Description: Affinity purified Mouse polyclonal Human Cyclin D1 antibody |
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Cyclin-D1/ Rat Cyclin- D1 ELISA Kit |
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| ELA-E0585r | Lifescience Market | 96 Tests | EUR 886 |
Cyclin D1 Polyclonal Antibody |
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| ES8274-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC |
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Cyclin D1 Polyclonal Antibody |
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| ES8274-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC |
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Cyclin D1 Polyclonal Antibody |
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| ES7017-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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Cyclin D1 Polyclonal Antibody |
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| ES7017-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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Cyclin D1 Polyclonal Antibody |
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| ES2081-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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Cyclin D1 Polyclonal Antibody |
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| ES2081-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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Cyclin D1 Polyclonal Antibody |
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| EA245-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC |
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Cyclin D1 Polyclonal Antibody |
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| EA245-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC |
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Anti-Cyclin D1 antibody |
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| STJ180082 | St John's Laboratory | 0.1 ml | EUR 246 |
Anti-Cyclin D1 antibody |
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| STJ180381 | St John's Laboratory | 0.1 ml | EUR 231 |
Cyclin D1 Polyclonal Antibody |
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| ABP51082-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Human, Mouse, Rat. This Cyclin D1 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Cyclin D1 around the non-phosphorylation site of T286 |
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Cyclin D1 Polyclonal Antibody |
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| ABP51082-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Human, Mouse, Rat. This Cyclin D1 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Cyclin D1 around the non-phosphorylation site of T286 |
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Cyclin D1 Polyclonal Antibody |
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| ABP51082-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Human, Mouse, Rat. This Cyclin D1 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Cyclin D1 around the non-phosphorylation site of T286 |
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Cyclin D1 Polyclonal Antibody |
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| ABP57275-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Mouse, Rat. This Cyclin D1 antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein |
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Cyclin D1 Polyclonal Antibody |
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| ABP57275-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Mouse, Rat. This Cyclin D1 antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein |
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Cyclin D1 Polyclonal Antibody |
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| ABP57275-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Mouse, Rat. This Cyclin D1 antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein |
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Cyclin D1 Polyclonal Antibody |
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| ABP56018-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Human, Mouse, Rat. This Cyclin D1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Cyclin D1 around the non-phosphorylation site of S90 |
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Cyclin D1 Polyclonal Antibody |
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| ABP56018-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Human, Mouse, Rat. This Cyclin D1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Cyclin D1 around the non-phosphorylation site of S90 |
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Cyclin D1 Polyclonal Antibody |
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| ABP56018-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Human, Mouse, Rat. This Cyclin D1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Cyclin D1 around the non-phosphorylation site of S90 |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx125309 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx125624 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| abx117083-100ug | Abbexa | 100 ug | EUR 467 |
Cyclin D1 (pT286) Antibody |
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| 20-abx121863 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx121864 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx123072 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx109797 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx123414 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx001183 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx100478 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx100479 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx100480 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx100481 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx100482 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx100483 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| abx038356-100ug | Abbexa | 100 ug | EUR 391 |
Cyclin D1 (CCND1) Antibody |
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| abx034749-400ul | Abbexa | 400 ul | EUR 523 |
Cyclin D1 (CCND1) Antibody |
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| abx034749-80l | Abbexa | 80 µl | EUR 286 |
Cyclin D1 (CCND1) Antibody |
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| 20-abx133903 | Abbexa |
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Cyclin D1 (pS90) Antibody |
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| abx149011-100ug | Abbexa | 100 ug | EUR 439 |
Cyclin D1 (pT288) Antibody |
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| abx149012-100ug | Abbexa | 100 ug | EUR 439 |
Cyclin D1 (CCND1) Antibody |
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| abx140376-01mg | Abbexa | 0.1 mg | EUR 356 |
Cyclin D1 (CCND1) Antibody |
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| abx139064-01mg | Abbexa | 0.1 mg | EUR 425 |
Cyclin D1 (pS90) Antibody |
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| abx010300-100ug | Abbexa | 100 ug | EUR 439 |
Cyclin D1 (CCND1) Antibody |
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| abx011703-100ul | Abbexa | 100 ul | EUR 411 |
Cyclin D1 (pT286) Antibody |
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| 20-abx011704 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| abx025054-400ul | Abbexa | 400 ul | EUR 523 |
Cyclin D1 (CCND1) Antibody |
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| abx025054-80l | Abbexa | 80 µl | EUR 286 |
Cyclin D1 (CCND1) Antibody |
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| abx031337-400ul | Abbexa | 400 ul | EUR 523 |
Cyclin D1 (CCND1) Antibody |
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| abx031337-80l | Abbexa | 80 µl | EUR 286 |
Cyclin D1 (CCND1) Antibody |
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| abx019062-100ug | Abbexa | 100 ug | EUR 342 |
cyclin D1 (CCND1) Antibody |
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| abx432565-200ul | Abbexa | 200 ul | EUR 384 |
Cyclin D1 antibody (Biotin) |
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| abx445236-100ug | Abbexa | 100 ug | EUR 578 |
Cyclin D1 antibody (FITC) |
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| abx445237-100ug | Abbexa | 100 ug | EUR 565 |
Cyclin D1 antibody (HRP) |
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| abx445238-100ug | Abbexa | 100 ug | EUR 565 |
Cyclin D1 (CCND1) Antibody |
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| 20-abx242422 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx214178 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx214742 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| abx232124-100ug | Abbexa | 100 ug | EUR 481 |
Cyclin D1 (CCND1) Antibody |
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| 20-abx176052 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx171973 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| abx224352-100ug | Abbexa | 100 ug | EUR 411 |
Cyclin D1 (CCND1) Antibody |
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| abx224460-100ug | Abbexa | 100 ug | EUR 411 |
Cyclin D1 (CCND1) Antibody |
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| 20-abx330261 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx327057 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx328717 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| abx448573-100ug | Abbexa | 100 ug | EUR 523 |
Anti-Cyclin D1 antibody |
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| STJ97480 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to Cyclin D1. |
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Anti-Cyclin D1 antibody |
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| STJ97978 | St John's Laboratory | 100 µl | EUR 234 |
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Description: Mouse monoclonal to Cyclin D1. |
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Anti-Cyclin D1 antibody |
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| STJ92537 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to Cyclin D1. |
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Anti-Cyclin D1 antibody |
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| STJ92538 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Cyclin D1 is a protein encoded by the CCND1 gene which is approximately 33,7 kDa. Cyclin D1 is localised to the nucleus and cytoplasm. It is involved in CDK-mediated phosphorylation and removal of Cdc6, cyclins and cell cycle regulation. This protein falls under the highly conserved cyclin family. It is a regulatory component of the cyclin D1-CDK4 complex that phosphorylates and inhibits members of the retinoblastoma protein family including RB1 and regulates the cell-cycle during G1/S transition. Cyclin D1 is expressed in the nervous system, liver, skin, intestine and lung. Mutations in the CCND1 gene may result in multiple myeloma. STJ92538 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Cyclin D1 protein. |
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Anti-cyclin D1 antibody |
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| STJ73356 | St John's Laboratory | 100 µg | EUR 359 |
anti- Cyclin D1 antibody |
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| FNab02124 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against Cyclin D1 |
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Cyclin D1 Polyclonal Antibody |
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| 40803-100ul | SAB | 100ul | EUR 252 |
Cyclin D1 Polyclonal Antibody |
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| 40803-50ul | SAB | 50ul | EUR 187 |
Cyclin D1 Conjugated Antibody |
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| C48619 | SAB | 100ul | EUR 397 |
Cyclin D1 Conjugated Antibody |
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| C47994 | SAB | 100ul | EUR 397 |
Cyclin D1 antibody (Thr286) |
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| 70R-30874 | Fitzgerald | 100 ug | EUR 327 |
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Description: Rabbit polyclonal Cyclin D1 antibody (Thr286) |
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Analogously, PORTAL registers useful resource labels and tags whereas DOORS publishes useful resource places and descriptions with mapping of labels to places for the semantic net. BioPORT is proposed as a prototype PORTAL registry particular for the issue area of biomedical computing.