A Wnt survival guide: from flies to human disease.

A Wnt survival guide: from flies to human disease.

It has been 20 years since investigators discovered the hyperlink between the Drosophila wingless (Wg) gene and the vertebrate oncogene int-1, thus establishing the family of signaling proteins known as Wnts. Given that inception of the Wnt signaling space, there … Read More

The RSK family of kinases: emerging roles in cellular signalling.

The RSK family of kinases: emerging roles in cellular signalling.

The 90 kDa ribosomal S6 kinase (RSK) household of proteins is a gaggle of extremely conserved Ser/Thr kinases that regulate various mobile processes, resembling cell progress, cell motility, cell survival and cell proliferation. RSKs are downstream effectors of the Ras-extramobile signal-regulated kinase (ERK)/mitogen-activated … Read More

Fluorescence probes used for detection of reactive oxygen species.

Fluorescence probes used for detection of reactive oxygen species.

Endogenously produced pro-oxidant reactive species are important to life, being concerned in a number of organic features. Nevertheless, when overproduced (e.g. attributable to exogenous stimulation), or when the degrees of antioxidants grow to be severely depleted, these reactive species grow … Read More